Efficient DNA photocleavage by [Ru(bpy)2(dppn)]2+ with visible light

The population and reactivity of two low-lying excited states in [Ru(bpy)(2)(dppn)](2+) (bpy = 2,2'-bipyridine, dppn = benzo[i]dipyrido[3,2-a:2',3'-c]phenazine), a weakly emissive (3)MLCT state and a long-lived ligand-centered (3)pipi* state, lead to efficient photoinduced DNA damage....

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2010-04, Vol.46 (14), p.2426-2428
Main Authors: Sun, Yujie, Joyce, Lauren E, Dickson, Nicole M, Turro, Claudia
Format: Article
Language:English
Subjects:
Coordination Complexes - chemistry
DNA - chemistry
DNA - radiation effects
DNA Cleavage
Guanine - chemistry
Light
Organometallic Compounds - chemistry
Oxidation-Reduction
Photolysis
Reactive Oxygen Species - metabolism
Ruthenium - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The population and reactivity of two low-lying excited states in [Ru(bpy)(2)(dppn)](2+) (bpy = 2,2'-bipyridine, dppn = benzo[i]dipyrido[3,2-a:2',3'-c]phenazine), a weakly emissive (3)MLCT state and a long-lived ligand-centered (3)pipi* state, lead to efficient photoinduced DNA damage. Irradiation with visible light results in nearly complete DNA cleavage within 30 s (lambda(irr) > or = 455 nm), likely from the combined action of guanine oxidation and the production of reactive oxygen species derived from (1)O(2).
ISSN:1359-7345
1364-548X
DOI:10.1039/b925574e