Dietary chromones as antioxidant agents--the structural variable

This study reports an evaluation of the free radical scavenging ability of a series of chromone derivatives, in the light of their structural features and conformational behaviour. The 2,2-diphenyl-1-picrylhydrazyl radical (DPPH˙) test for the assessment of radical scavenging properties was applied,...

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Bibliographic Details
Published in:Food & function 2011-10, Vol.2 (10), p.595-602
Main Authors: Dias, M M, Machado, N F L, Marques, M P M
Format: Article
Language:English
Subjects:
Chromones - chemistry
Dietary Supplements - analysis
Free Radical Scavengers - chemistry
Molecular Structure
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Summary:This study reports an evaluation of the free radical scavenging ability of a series of chromone derivatives, in the light of their structural features and conformational behaviour. The 2,2-diphenyl-1-picrylhydrazyl radical (DPPH˙) test for the assessment of radical scavenging properties was applied, and the interpretation of the experimental results was assisted by ab initio theoretical approaches that allowed relevant parameters, such as the enthalpy of formation of the radical species, to be predicted. From the eighteen tested compounds, three-fisetin, luteolin and quercetin-are shown to act as effective antiradicals. Consistent structure-activity relationships (SARs) were established regarding the antioxidant role of this type of chromone-based system.
ISSN:2042-6496
2042-650X
DOI:10.1039/c1fo10098j