Recognition of thymine in DNA bulges by a Zn(II) macrocyclic complex

A Zn(II) macrocyclic complex with appended quinoline is a bifunctional recognition agent that uses both the Zn(II) center and the pendent aromatic group to bind to thymine in bulges with good selectivity over DNA containing G, C or A bulges. Spectroscopic studies show that the stem containing the bu...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2011-01, Vol.47 (30), p.8566-8568
Main Authors: del Mundo, Imee Marie A, Fountain, Matthew A, Morrow, Janet R
Format: Article
Language:English
Subjects:
Coordination Complexes - chemistry
DNA - chemistry
Macrocyclic Compounds - chemistry
Oligonucleotides - chemistry
Quinolines - chemistry
Thymine - chemistry
Zinc - chemistry
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Summary:A Zn(II) macrocyclic complex with appended quinoline is a bifunctional recognition agent that uses both the Zn(II) center and the pendent aromatic group to bind to thymine in bulges with good selectivity over DNA containing G, C or A bulges. Spectroscopic studies show that the stem containing the bulge stays largely intact in a DNA hairpin with the Zn(II) complex bound to the thymine bulge.
ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc12074c