Rac Mediates Mouse Spermatogonial Stem Cell Homing to Germline Niches by Regulating Transmigration through the Blood-Testis Barrier

The homing ability of spermatogonial stem cells (SSCs) allows them to migrate into niches after being transplantated into infertile testes. Transplanted SSCs attach to Sertoli cells and transmigrate through the blood-testis barrier (BTB), formed by inter-Sertoli tight junctions, toward niches on the...

Full description

Saved in:
Bibliographic Details
Published in:Cell stem cell 2011-11, Vol.9 (5), p.463-475
Main Authors: Takashima, Seiji, Kanatsu-Shinohara, Mito, Tanaka, Takashi, Takehashi, Masanori, Morimoto, Hiroko, Shinohara, Takashi
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood-Testis Barrier - cytology
Blood-Testis Barrier - metabolism
Cell differentiation, maturation, development, hematopoiesis
Cell physiology
Cell Shape
Cells, Cultured
Colony-Forming Units Assay
Embryo, Mammalian - cytology
Enzyme Activation
Fibroblasts - cytology
Fibroblasts - metabolism
Fundamental and applied biological sciences. Psychology
Gene Deletion
Gene Expression Regulation
Male
Mice
Mice, Knockout
Molecular and cellular biology
Mutation - genetics
Neuropeptides - genetics
Neuropeptides - metabolism
rac GTP-Binding Proteins - genetics
rac GTP-Binding Proteins - metabolism
rac1 GTP-Binding Protein
Spermatogonia - cytology
Spermatogonia - metabolism
Spermatogonia - transplantation
Stem Cell Niche
Stem Cells - cytology
Stem Cells - metabolism
Tight Junctions - metabolism
Transendothelial and Transepithelial Migration
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The homing ability of spermatogonial stem cells (SSCs) allows them to migrate into niches after being transplantated into infertile testes. Transplanted SSCs attach to Sertoli cells and transmigrate through the blood-testis barrier (BTB), formed by inter-Sertoli tight junctions, toward niches on the basement membrane. The most critical step is the passage through the BTB, which limits the homing efficiency to
ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2011.08.011