Developmental toxicity assessment of the ionic liquid 1-butyl-3-methylimidazolium chloride in CD-1 mice

The effects of prenatal exposure of mice to the ionic liquid (IL) 1-butyl-3-methylimidazolium chloride ([C4mim]Cl) were studied because of the potential for human exposure as a result of water or soil contamination from industrial effluent or accidental spills. After exposure to the IL, fetal weight...

Full description

Saved in:
Bibliographic Details
Published in:Green chemistry : an international journal and green chemistry resource : GC 2008-01, Vol.10 (11), p.1213-1217
Main Authors: Bailey, Melissa M., Townsend, Megan B., Jernigan, Peter L., Sturdivant, John, Hough-Troutman, Whitney L., Rasco, Jane F., Swatloski, Richard P., Rogers, Robin D., Hood, Ronald D.
Format: Article
Language:English
Subjects:
Chlorides
green development
Industrial effluents
Mice
Morbidity
Mortality
prenatal experience
soil contamination
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effects of prenatal exposure of mice to the ionic liquid (IL) 1-butyl-3-methylimidazolium chloride ([C4mim]Cl) were studied because of the potential for human exposure as a result of water or soil contamination from industrial effluent or accidental spills. After exposure to the IL, fetal weight was significantly decreased at the two highest dosages (P[less-than-or-equal] 0.01). Malformations were also somewhat more numerous at the highest dosage, suggesting that [C4mim]Cl may be teratogenic, although the apparent increase was not statistically significant. Maternal toxicity was also present, as shown by a dose-dependent increase in maternal morbidity and mortality during the course of treatment. Therefore from these results, [C4mim]Cl appears to be developmentally toxic at maternally toxic dosages, although the mechanism is unknown.
ISSN:1463-9262
1463-9270
DOI:10.1039/b807019a