Exploring the Genomes of Cancer Cells: Progress and Promise

The description and interpretation of genomic abnormalities in cancer cells have been at the heart of cancer research for more than a century. With exhaustive sequencing of cancer genomes across a wide range of human tumors well under way, we are now entering the end game of this mission. In the for...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2011-03, Vol.331 (6024), p.1553-1558
Main Author: Stratton, Michael R.
Format: Article
Language:English
Subjects:
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Cancer
DNA
DNA Repair
Drug Discovery
Genes
Genes, Neoplasm
Genetic mutation
Genetic Techniques
Genome, Human
Genomes
Genomics
Humans
Molecular Targeted Therapy
Mutation
Neoplasm Metastasis
Neoplasms - diagnosis
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - pathology
Oncogenes
REVIEWS
Sequence Analysis, DNA
Sequencing
Somatic mutation
Tumors
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Summary:The description and interpretation of genomic abnormalities in cancer cells have been at the heart of cancer research for more than a century. With exhaustive sequencing of cancer genomes across a wide range of human tumors well under way, we are now entering the end game of this mission. In the forthcoming decade, essentially complete catalogs of somatic mutations will be generated for tens of thousands of human cancers. Here, I provide an overview of what these efforts have revealed to data about the origin and behavioral features of cancer cells and how this genomic information is being exploited to improve diagnosis and therapy of the disease.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1204040