Mitochondrial Capture by a Transmissible Cancer

Canine transmissible venereal tumor (CTVT) is an infectious cell line circulating in many feral dog populations. It originated once, about 10,000 years ago. Phylogenetic analyses of mitochondrial sequences from dogs, wolves, and a geographically diverse collection of CTVT samples indicate that the c...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2011-01, Vol.331 (6015), p.303-303
Main Authors: Rebbeck, Clare A, Leroi, Armand M, Burt, Austin
Format: Article
Language:English
Subjects:
Animal diseases
Animal tumors. Experimental tumors
Animals
Biological and medical sciences
BREVIA
Cancer
Circulating
Collection
Coyotes - genetics
Disease transmission
Dog Diseases - genetics
Dog Diseases - metabolism
Dog Diseases - pathology
Dogs
Dogs - genetics
Evolution
Experimental tumors, general aspects
Gene Transfer, Horizontal
Genetic mutation
Genome, Mitochondrial
Medical sciences
Mitochondria
Mitochondria - genetics
Mitochondria - metabolism
Mutation
Mutations
Parsimony
Phylogeny
Polymorphism, Genetic
Populations
Selection, Genetic
Sequence Analysis, DNA
Tumors
Venereal Tumors, Veterinary - genetics
Venereal Tumors, Veterinary - metabolism
Venereal Tumors, Veterinary - pathology
Wolves
Wolves - genetics
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Summary:Canine transmissible venereal tumor (CTVT) is an infectious cell line circulating in many feral dog populations. It originated once, about 10,000 years ago. Phylogenetic analyses of mitochondrial sequences from dogs, wolves, and a geographically diverse collection of CTVT samples indicate that the cancer has periodically acquired mitochondria from its host. We suggest that this may be because the cancer's own mitochondria have a tendency to degenerate, due to high mutation rates and relaxed selection, resulting in host mitochondria being more fit.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1197696