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Mitochondrial Capture by a Transmissible Cancer
Canine transmissible venereal tumor (CTVT) is an infectious cell line circulating in many feral dog populations. It originated once, about 10,000 years ago. Phylogenetic analyses of mitochondrial sequences from dogs, wolves, and a geographically diverse collection of CTVT samples indicate that the c...
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| Published in: | Science (American Association for the Advancement of Science) 2011-01, Vol.331 (6015), p.303-303 |
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| cites | cdi_FETCH-LOGICAL-c529t-450ef5c19966f112e18a95d2761888b9f69e71821e2542859b00dc85739cda423 |
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| container_issue | 6015 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Rebbeck, Clare A Leroi, Armand M Burt, Austin |
| description | Canine transmissible venereal tumor (CTVT) is an infectious cell line circulating in many feral dog populations. It originated once, about 10,000 years ago. Phylogenetic analyses of mitochondrial sequences from dogs, wolves, and a geographically diverse collection of CTVT samples indicate that the cancer has periodically acquired mitochondria from its host. We suggest that this may be because the cancer's own mitochondria have a tendency to degenerate, due to high mutation rates and relaxed selection, resulting in host mitochondria being more fit. |
| doi_str_mv | 10.1126/science.1197696 |
| format | article |
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It originated once, about 10,000 years ago. Phylogenetic analyses of mitochondrial sequences from dogs, wolves, and a geographically diverse collection of CTVT samples indicate that the cancer has periodically acquired mitochondria from its host. We suggest that this may be because the cancer's own mitochondria have a tendency to degenerate, due to high mutation rates and relaxed selection, resulting in host mitochondria being more fit.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1197696</identifier><identifier>PMID: 21252340</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Animal diseases ; Animal tumors. 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It originated once, about 10,000 years ago. Phylogenetic analyses of mitochondrial sequences from dogs, wolves, and a geographically diverse collection of CTVT samples indicate that the cancer has periodically acquired mitochondria from its host. We suggest that this may be because the cancer's own mitochondria have a tendency to degenerate, due to high mutation rates and relaxed selection, resulting in host mitochondria being more fit.</description><subject>Animal diseases</subject><subject>Animal tumors. Experimental tumors</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>BREVIA</subject><subject>Cancer</subject><subject>Circulating</subject><subject>Collection</subject><subject>Coyotes - genetics</subject><subject>Disease transmission</subject><subject>Dog Diseases - genetics</subject><subject>Dog Diseases - metabolism</subject><subject>Dog Diseases - pathology</subject><subject>Dogs</subject><subject>Dogs - genetics</subject><subject>Evolution</subject><subject>Experimental tumors, general aspects</subject><subject>Gene Transfer, Horizontal</subject><subject>Genetic mutation</subject><subject>Genome, Mitochondrial</subject><subject>Medical sciences</subject><subject>Mitochondria</subject><subject>Mitochondria - genetics</subject><subject>Mitochondria - metabolism</subject><subject>Mutation</subject><subject>Mutations</subject><subject>Parsimony</subject><subject>Phylogeny</subject><subject>Polymorphism, Genetic</subject><subject>Populations</subject><subject>Selection, Genetic</subject><subject>Sequence Analysis, DNA</subject><subject>Tumors</subject><subject>Venereal Tumors, Veterinary - genetics</subject><subject>Venereal Tumors, Veterinary - metabolism</subject><subject>Venereal Tumors, Veterinary - pathology</subject><subject>Wolves</subject><subject>Wolves - genetics</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFkc1P3DAQxa2qFWwp555KV5UqTunO-HuOaEVbJCoOwDlyHKfNKpssdnLgv8erTUHiwsmy3s_Pb-Yx9hnhByLXq-Tb0PuQL2Q06XdsgUCqIA7iPVsACF1YMOqYfUxpA5A1EkfsmCNXXEhYsNWfdhz8v6GvY-u65drtximGZfW4dMu76Pq0bVNqqy5kKX8UP7EPjetSOJ3PE3b_8_Ju_bu4vvl1tb64LrziNBZSQWiURyKtm5w0oHWkam40WmsrajQFg5Zj4Epyq6gCqL1VRpCvneTihJ0ffHdxeJhCGsscxIeuc30YplQSGBKCW_MmaZUyeR2Ib5NSW7IINpPfXpGbYYp9HjhDyqJUUmRodYB8HFKKoSl3sd26-FgilPt2yrmdcm4nvzibbadqG-pn_n8dGfg-Ay551zW5AN-mF07Yfb37fF8O3CaNQ3zWJZDV2uwn_XrQGzeU7m_MHve3HFAAkpCaSDwBsWinrg</recordid><startdate>20110121</startdate><enddate>20110121</enddate><creator>Rebbeck, Clare A</creator><creator>Leroi, Armand M</creator><creator>Burt, Austin</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20110121</creationdate><title>Mitochondrial Capture by a Transmissible Cancer</title><author>Rebbeck, Clare A ; Leroi, Armand M ; Burt, Austin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-450ef5c19966f112e18a95d2761888b9f69e71821e2542859b00dc85739cda423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animal diseases</topic><topic>Animal tumors. 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It originated once, about 10,000 years ago. Phylogenetic analyses of mitochondrial sequences from dogs, wolves, and a geographically diverse collection of CTVT samples indicate that the cancer has periodically acquired mitochondria from its host. We suggest that this may be because the cancer's own mitochondria have a tendency to degenerate, due to high mutation rates and relaxed selection, resulting in host mitochondria being more fit.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>21252340</pmid><doi>10.1126/science.1197696</doi><tpages>1</tpages></addata></record> |
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| ispartof | Science (American Association for the Advancement of Science), 2011-01, Vol.331 (6015), p.303-303 |
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| subjects | Animal diseases Animal tumors. Experimental tumors Animals Biological and medical sciences BREVIA Cancer Circulating Collection Coyotes - genetics Disease transmission Dog Diseases - genetics Dog Diseases - metabolism Dog Diseases - pathology Dogs Dogs - genetics Evolution Experimental tumors, general aspects Gene Transfer, Horizontal Genetic mutation Genome, Mitochondrial Medical sciences Mitochondria Mitochondria - genetics Mitochondria - metabolism Mutation Mutations Parsimony Phylogeny Polymorphism, Genetic Populations Selection, Genetic Sequence Analysis, DNA Tumors Venereal Tumors, Veterinary - genetics Venereal Tumors, Veterinary - metabolism Venereal Tumors, Veterinary - pathology Wolves Wolves - genetics |
| title | Mitochondrial Capture by a Transmissible Cancer |
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