Comparative study between chloramine-T and iodogen to prepare radioiodinated etodolac for inflammation imaging

This study describes a fast and efficient method for radiolabeling of etodolac with iodine-125 [ 125 I], where both chloramine-T and iodogen were used as oxidizing agents. The labeling reaction was carried out via electrophilic substitution of hydrogen atom with the iodonium cation I + . The labelin...

Full description

Saved in:
Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry 2011-04, Vol.288 (1), p.9-15
Main Authors: Hussien, H., Goud, A. A., Amin, A. M., EL-Sheikh, R., Seddik, U.
Format: Article
Language:English
Subjects:
Acetates
Cations
Chemistry
Chemistry and Materials Science
Chlorides
Diagnostic Radiology
Electrophoresis
Hadrons
Heavy Ions
Inorganic Chemistry
Marking
Methylene
Nuclear Chemistry
Nuclear Physics
Oxidizing agents
Physical Chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study describes a fast and efficient method for radiolabeling of etodolac with iodine-125 [ 125 I], where both chloramine-T and iodogen were used as oxidizing agents. The labeling reaction was carried out via electrophilic substitution of hydrogen atom with the iodonium cation I + . The labeling yield was found to be influenced by different factors such as drug concentration, pH of the reaction mixtures, different oxidizing agents, reaction time, temperature and different organic media. The radiochemical yield (RCY) was determined by TLC system using methylene chloride:ethyl acetate (3:7 v/v) as a developing solvent and by electrophoresis using cellulose acetate moistened with 0.02 M phosphate buffer pH 7. The maximum radiochemical yield of [ 125 I]Etodolac (87.7%) was obtained. Labeled etodolac shows a good localization in inflamed muscle. It excretes mainly via kidney and to some via liver.
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-010-0967-9