Toxic effects of inhaled manganese on the olfactory bulb: an ultrastructural approach in mice

Olfactory dysfunction is a common symptom reported by patients with neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Despite the knowledge gathered about the pathology of these diseases, little information has been generated regarding the ultrastructure modificatio...

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Bibliographic Details
Published in:Journal of electron microscopy 2011-02, Vol.60 (1), p.73-78
Main Authors: Colin-Barenque, L, Souza-Gallardo, L M, Fortoul, T I
Format: Article
Language:English
Subjects:
Air pollution
Air Pollution - adverse effects
Animals
Apoptosis
Cells
Chlorides - toxicity
Correlation analysis
Cytoskeleton
Diseases
Disorders
Granular materials
Inhalation Exposure
Male
Manganese
Manganese - toxicity
Manganese Compounds
Membranes
Mice
Necrosis
Nerve Degeneration
Neurons - pathology
Neurons - ultrastructure
Olfaction Disorders - chemically induced
Olfaction Disorders - pathology
Olfactory Bulb - drug effects
Organelles - ultrastructure
Patients
Rodents
Smell
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Summary:Olfactory dysfunction is a common symptom reported by patients with neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Despite the knowledge gathered about the pathology of these diseases, little information has been generated regarding the ultrastructure modifications of the granule cells that regulate the information for odor identification. Swollen organelles and nuclear invaginations identified the exposed mice. Necrosis was evidenced at 4th week of exposure, whereas apoptosis arose at 8th week of exposure. A ruffled electron-dense membrane changes were also found. The changes observed could be explained by the reactive oxygen species generated by manganese and its effects on the membrane's structure and on the cytoskeleton's function. This study contributes to correlate metal air pollution and neurodegenerative changes with olfactory affection.
ISSN:0022-0744
1477-9986
2050-5701
DOI:10.1093/jmicro/dfq073