Low-level laser therapy supported teeth extractions of two patients receiving IV zolendronate

BRONJ (bisphosphonate-related osteonecrosis of jaws) is a frequently encountered disease, particularly in the maxillofacial region, and a consequence of bisphosphonate use. Treatment of BRONJ remains controversial, as efficiency of medical and surgical approaches as well as a combination of these me...

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Bibliographic Details
Published in:Lasers in medical science 2011-09, Vol.26 (5), p.569-575
Main Authors: Kan, Bahadır, Altay, Mehmet Ali, Taşar, Ferda, Akova, Murat
Format: Article
Language:English
Subjects:
Antibiotics
Biomedical materials
Bisphosphonate-Associated Osteonecrosis of the Jaw - etiology
Bisphosphonate-Associated Osteonecrosis of the Jaw - prevention & control
Bone Density Conservation Agents - administration & dosage
Bone Density Conservation Agents - adverse effects
Bones
Breast Neoplasms - therapy
Dentistry
Diphosphonates - administration & dosage
Diphosphonates - adverse effects
Drug therapy
Female
Humans
Infusions, Intravenous
Lasers
Low-Level Light Therapy
Male
Medicine
Medicine & Public Health
Middle Aged
Mouth
Multiple Myeloma - therapy
Optical Devices
Optics
Original Article
Patients
Photonics
Prophylaxis
Quantum Optics
Receiving
Risk Factors
Side effects
Teeth
Therapy
Tooth Extraction - methods
Wound healing
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Summary:BRONJ (bisphosphonate-related osteonecrosis of jaws) is a frequently encountered disease, particularly in the maxillofacial region, and a consequence of bisphosphonate use. Treatment of BRONJ remains controversial, as efficiency of medical and surgical approaches as well as a combination of these methods with supportive treatments have not been clearly demonstrated in the literature. In recent years, laser usage alone or in combination with the main therapy methods, has become popular for the treatment of bisphosphonate-related osteo-necrosis of jaws. In this article, we present the successful management of two dental patients who had high potentials for BRONJ development as a result of chemo and radiotherapy combined with IV zoledronic acid application. Multiple consecutive teeth extractions followed with primary wound closure and LLLT applications were performed under high doses of antibiotics prophylaxis. Satisfactory wound healing in both the surrounding soft and hard tissues was achieved. LLLT application combined with atraumatic surgical interventions under antibiotics prophylaxis is a preferable approach in patients with a risk of BRONJ development. Adjunctive effect of LLLT in addition to careful infection control on preventing BRONJ was reported and concluded.
ISSN:0268-8921
1435-604X
DOI:10.1007/s10103-010-0816-7