The influence of the compounding process and testing conditions on the compressive mechanical properties of poly(D,L-lactide-co-glycolide)/ α -tricalcium phosphate nanocomposites

The enhanced biological and degradation properties of bioresorbable polymer matrix nanocomposites intended for use in orthopaedic applications have been demonstrated recently. However, at the moment there are only limited reports addressing their mechanical properties under physiological conditions,...

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Bibliographic Details
Published in:Journal of the mechanical behavior of biomedical materials 2011-10, Vol.4 (7), p.1081-1089
Main Authors: Wilberforce, Samuel I.J., Finlayson, Chris E., Best, Serena M., Cameron, Ruth E.
Format: Article
Language:English
Subjects:
Biomedical materials
Buffers
Calcium Phosphates - chemistry
Compressive modulus
Compressive Strength
Degradation
Drying
Glass transition temperature
Immersion
Lactic Acid - chemistry
Materials Testing
Mechanical properties
Nanocomposite
Nanocomposites
Nanocomposites - chemistry
Particle Size
Phosphates
Poly(D,L-lactide-co-glycolide)
Polyglycolic Acid - chemistry
Surgical implants
Temperature
Thermogravimetry
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Summary:The enhanced biological and degradation properties of bioresorbable polymer matrix nanocomposites intended for use in orthopaedic applications have been demonstrated recently. However, at the moment there are only limited reports addressing their mechanical properties under physiological conditions, which is of central importance to the successful design of these nanocomposites. Here, we show that at room temperature in dry conditions, the incorporation of α -tricalcium phosphate nanoparticles into a matrix of poly(D,L-lactide-co-glycolide) increases the compressive strength and modulus. The values at room temperature obtained for nanocomposites compounded by a modified solvent evaporation method via attrition milling in acetone were similar to those from samples compounded by twin screw extrusion. The values for nanocomposites tested at 37 °C in phosphate buffered saline solution were significantly lower than those tested at room temperature in dry conditions, and lower still after two weeks of degradation in PBS at 37 °C. These effects can be related to hydration, degradation and interface effects in the nanocomposites.
ISSN:1751-6161
1878-0180
DOI:10.1016/j.jmbbm.2011.03.017