Target recognition, resistance, immunity and genome mining of class II bacteriocins from Gram-positive bacteria

Due to their very potent antimicrobial activity against diverse food-spoiling bacteria and pathogens and their favourable biochemical properties, peptide bacteriocins from Gram-positive bacteria have long been considered promising for applications in food preservation or medical treatment. To take a...

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Bibliographic Details
Published in:Microbiology (Society for General Microbiology) 2011-12, Vol.157 (Pt 12), p.3256-3267
Main Authors: KJOS, Morten, BORRERO, Juan, OPSATA, Mona, BIRRI, Dagim J, HOLO, Helge, CINTAS, Luis M, SNIPEN, Lars, HERNANDEZ, Pablo E, NES, Ingolf F, DIEP, Dzung B
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - metabolism
Bacteria
Bacteriocins - genetics
Bacteriocins - metabolism
Biological and medical sciences
Computational Biology
Drug Resistance, Bacterial
Fundamental and applied biological sciences. Psychology
Genome, Bacterial
Gram-Positive Bacteria - drug effects
Gram-Positive Bacteria - genetics
Gram-Positive Bacteria - metabolism
Microbiology
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Summary:Due to their very potent antimicrobial activity against diverse food-spoiling bacteria and pathogens and their favourable biochemical properties, peptide bacteriocins from Gram-positive bacteria have long been considered promising for applications in food preservation or medical treatment. To take advantage of bacteriocins in different applications, it is crucial to have detailed knowledge on the molecular mechanisms by which these peptides recognize and kill target cells, how producer cells protect themselves from their own bacteriocin (self-immunity) and how target cells may develop resistance. In this review we discuss some important recent progress in these areas for the non-lantibiotic (class II) bacteriocins. We also discuss some examples of how the current wealth of genome sequences provides an invaluable source in the search for novel class II bacteriocins.
ISSN:1350-0872
1465-2080
DOI:10.1099/mic.0.052571-0