Antinociceptive activity of discretamine isolated from Duguetia moricandiana

• Published in: Natural product research 2011-12, Vol.25 (20), p.1908-1915
• Main Authors: Almeida, J.R.G.S., de Lima, J.T., de Oliveira, H.R., de Oliveira, M.R., Meira, P.R.M., Lúcio, A.S.S.C., Barbosa Filho, J.M., Quintans Júnior, L.J.
• Format: Article
• Language: English
• Subjects: Acetic Acid; Analgesics - isolation & purification; Analgesics - pharmacology; Analgesics - therapeutic use; Analysis of Variance; Animals; Annonaceae; Annonaceae - chemistry; antinociceptive activity; Berberine Alkaloids - chemistry; Berberine Alkaloids - isolation & purification; Berberine Alkaloids - pharmacology; Berberine Alkaloids - therapeutic use; Chromatography; discretamine; Dose-Response Relationship, Drug; Duguetia moricandiana; Formaldehyde; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Structure; Pain - drug therapy; Pain Measurement; Plant Extracts - chemistry
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2010.491227

The phytochemical study of Duguetia moricandiana Mart. (Annonaceae) yielded the isolation of the alkaloid which was identified by spectral analysis as discretamine. The evaluation of antinociceptive activity carried out by the acetic acid-induced writhing, formalin and hot plate tests in mice, suggests a potent antinociceptive effect. Discretamine (5, 10 and 20 mg kg −1 , i.p.) significantly reduced the number of writhes similarly at all doses tested and the number of paw licks during the first phase of formalin test when compared to control. The effect of discretamine on hot plate response provides a confirmation of its central effect. These results indicate antinociceptive properties of this alkaloid.