Plasma concentrations of interleukin-6, C-reactive protein, tumor necrosis factor-α and matrix metalloproteinase-9 in aortic dissection

The role of inflammation in aortic dissection (AD) has not fully been investigated. We evaluated the potential relationships between interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and matrix metalloproteinase-9 (MMP-9) and AD. Plasma concentrations of IL-6, TNF-α, M...

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Published in:Clinica chimica acta 2012-01, Vol.413 (1-2), p.198-202
Main Authors: Wen, Dan, Zhou, Xian-Liang, Li, Jian-Jun, Luo, Fang, Zhang, Lin, Gao, Ling-Gen, Wang, Lin-Ping, Song, Lei, Sun, Kai, Zou, Yu-Bao, Zhang, Chan-Na, Hui, Ru-Tai
Format: Article
Language:English
Subjects:
Aneurysm, Dissecting - blood
Aortic Aneurysm - blood
Aortic dissection
Biomarkers - blood
C-reactive protein
C-Reactive Protein - metabolism
Humans
Inflammation
Interleukin-6
Interleukin-6 - blood
Matrix Metalloproteinase 9 - blood
Matrix metalloproteinase-9
Tumor Necrosis Factor-alpha - blood
Tumor necrosis factor-α
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Summary:The role of inflammation in aortic dissection (AD) has not fully been investigated. We evaluated the potential relationships between interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and matrix metalloproteinase-9 (MMP-9) and AD. Plasma concentrations of IL-6, TNF-α, MMP-9 and CRP were determined in 64 acute AD patients, 42 patients with chronic AD, 98 patients with hypertension alone, and 96 healthy subjects. IL-6 concentrations were higher in acute AD than that in hypertension and healthy controls (10.98±2.38 vs. 3.79±1.56 and 3.32±1.60pg/ml, P
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2011.09.029