The effects of shear flow on protein structure and function

Protein molecules are subjected to potentially denaturing fluid shear forces during processing and in circulation in the body. These complex molecules, involved in numerous biological functions and reactions, can be significantly impaired by molecular damage. There have been many studies on the effe...

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Bibliographic Details
Published in:Biopolymers 2011-11, Vol.95 (11), p.733-745
Main Authors: Bekard, Innocent B., Asimakis, Peter, Bertolini, Joseph, Dunstan, Dave E.
Format: Article
Language:English
Subjects:
aggregation
amyloid fibril
Biopolymers
Bioprocessing
Fluid dynamics
Fluid flow
Fluids
Models, Molecular
Molecular structure
physiology
protein
Protein Conformation
Proteins
Proteins - chemistry
Shear
shear flow
Solutions
unfolding
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Summary:Protein molecules are subjected to potentially denaturing fluid shear forces during processing and in circulation in the body. These complex molecules, involved in numerous biological functions and reactions, can be significantly impaired by molecular damage. There have been many studies on the effects of hydrodynamic shear forces on protein structure and function. These studies are reviewed and the implications to bioprocessing and pathophysiology of certain diseases are discussed. © 2011 Wiley Periodicals, Inc. Biopolymers 95: 733‐745, 2011.
ISSN:0006-3525
1097-0282
1097-0282
DOI:10.1002/bip.21646