Synthesis and in vitro evaluation of palladium(II) salicylaldiminato thiosemicarbazone complexes against Trichomonas vaginalis

Eight mononuclear Pd(II) complexes containing salicylaldiminato thiosemicarbazones (saltsc-R; where R = H ( 1), 3-OMe ( 2), 3- t Bu ( 3) and 5-Cl ( 4)) as dinegative tridentate ligands were prepared by the reaction of the corresponding thiosemicarbazone with the precursor Pd(L) 2Cl 2 (L = phosphatri...

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Bibliographic Details
Published in:Journal of inorganic biochemistry 2011-12, Vol.105 (12), p.1562-1568
Main Authors: Chellan, Prinessa, Stringer, Tameryn, Shokar, Ajit, Dornbush, Padraick J., Vazquez-Anaya, Guillermo, Land, Kirkwood M., Chibale, Kelly, Smith, Gregory S.
Format: Article
Language:English
Subjects:
Antiparasital activity
Antiprotozoal Agents - chemical synthesis
Antiprotozoal Agents - pharmacology
Coordination Complexes - chemical synthesis
Coordination Complexes - pharmacology
Crystallography, X-Ray
Inhibitory Concentration 50
Models, Molecular
Molecular Conformation
Palladium
Pd(II) complexes
Thiosemicarbazones
Thiosemicarbazones - chemical synthesis
Thiosemicarbazones - pharmacology
Trichomonas vaginalis
Trichomonas vaginalis - drug effects
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Summary:Eight mononuclear Pd(II) complexes containing salicylaldiminato thiosemicarbazones (saltsc-R; where R = H ( 1), 3-OMe ( 2), 3- t Bu ( 3) and 5-Cl ( 4)) as dinegative tridentate ligands were prepared by the reaction of the corresponding thiosemicarbazone with the precursor Pd(L) 2Cl 2 (L = phosphatriazaadamantane or 4-picoline) in the presence of a weak base. These complexes ( 9– 16) were characterised by a range of spectroscopic and analytical techniques including NMR spectroscopy and X-ray diffraction. These complexes along with four other Pd(II) analogues ( 5– 8) were screened for activity in vitro against the Trichomonas vaginalis parasite. Preliminary results show that the type of ancillary ligand as well as the substituents on the aromatic ring of the salicylaldiminato thiosemicarbazone ligand influences the antiparasitic activity of these complexes. Mononuclear palladium(II) complexes containing salicylaldiminato thiosemicarbazones as dinegative tridentate ligands were synthesised. The biological activity of the palladium complexes were evaluated against the Trichomonas vaginalis parasite. [Display omitted]
ISSN:0162-0134
1873-3344
DOI:10.1016/j.jinorgbio.2011.07.023