Evaluation of the Stability and Antioxidant Activity of Nanoencapsulated Resveratrol during in Vitro Digestion

Resveratrol was encapsulated in oil-in-water food-grade nanoemulsions of subcellular size, produced by high-pressure homogenization. Physicochemical stability was evaluated under accelerated aging (high temperature and UV light exposure), as well as during simulated gastrointestinal digestion. Antio...

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Published in:Journal of agricultural and food chemistry 2011-12, Vol.59 (23), p.12352-12360
Main Authors: Sessa, Mariarenata, Tsao, Rong, Liu, Ronghua, Ferrari, Giovanna, Donsì, Francesco
Format: Article
Language:English
Subjects:
Antioxidants - chemistry
Antioxidants - pharmacology
Bioactive Constituents
Biological and medical sciences
Caco-2 Cells
Capsules
Chemistry, Pharmaceutical
Digestion
Drug Stability
Emulsions
Food industries
Fundamental and applied biological sciences. Psychology
Humans
In Vitro Techniques
Nanotechnology
Stilbenes - metabolism
Stilbenes - pharmacokinetics
Stilbenes - pharmacology
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cites cdi_FETCH-LOGICAL-a344t-1e1b113929dfb31029a62ef99636b3f80c503d9a9800d2b23a177668089c26593
container_end_page 12360
container_issue 23
container_start_page 12352
container_title Journal of agricultural and food chemistry
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creator Sessa, Mariarenata
Tsao, Rong
Liu, Ronghua
Ferrari, Giovanna
Donsì, Francesco
description Resveratrol was encapsulated in oil-in-water food-grade nanoemulsions of subcellular size, produced by high-pressure homogenization. Physicochemical stability was evaluated under accelerated aging (high temperature and UV light exposure), as well as during simulated gastrointestinal digestion. Antioxidant activity was assessed at different stages of digestion by chemical assays and by an improved cellular assay, to measure exclusively the residual activity of resveratrol that penetrated inside Caco-2 cells. Results showed that the nanoemulsions based on soy lecithin/sugar esters and Tween 20/glycerol monooleate were the most physically and chemically stable, in terms of mean droplet size (always
doi_str_mv 10.1021/jf2031346
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source American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects Antioxidants - chemistry
Antioxidants - pharmacology
Bioactive Constituents
Biological and medical sciences
Caco-2 Cells
Capsules
Chemistry, Pharmaceutical
Digestion
Drug Stability
Emulsions
Food industries
Fundamental and applied biological sciences. Psychology
Humans
In Vitro Techniques
Nanotechnology
Stilbenes - metabolism
Stilbenes - pharmacokinetics
Stilbenes - pharmacology
title Evaluation of the Stability and Antioxidant Activity of Nanoencapsulated Resveratrol during in Vitro Digestion
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