Effect of pregabalin on post-dural-puncture headache following spinal anesthesia and lumbar puncture

Abstract In this study, we aimed to investigate the effect of pregabalin on post-dural-puncture headache (PDPH). Forty patients who developed PDPH after spinal anesthesia or diagnostic and/or therapeutic lumbar puncture were divided into two groups and followed for 5 days. The first group received 1...

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Bibliographic Details
Published in:Journal of clinical neuroscience 2011-10, Vol.18 (10), p.1365-1368
Main Authors: Huseyinoglu, U, Huseyinoglu, N, Hamurtekin, E, Aygun, H, Sulu, B
Format: Article
Language:English
Subjects:
Adult
Anesthesia, Spinal - adverse effects
Female
gamma-Aminobutyric Acid - analogs & derivatives
gamma-Aminobutyric Acid - pharmacology
gamma-Aminobutyric Acid - therapeutic use
Headache
Humans
Lumbar puncture
Male
Middle Aged
Neurology
Pain Measurement - drug effects
Pain Measurement - methods
Post-Dural Puncture Headache - drug therapy
Post-Dural Puncture Headache - etiology
Pregabalin
Prospective Studies
Single-Blind Method
Spinal anesthesia
Spinal Puncture - adverse effects
Young Adult
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Summary:Abstract In this study, we aimed to investigate the effect of pregabalin on post-dural-puncture headache (PDPH). Forty patients who developed PDPH after spinal anesthesia or diagnostic and/or therapeutic lumbar puncture were divided into two groups and followed for 5 days. The first group received 150 mg/day oral pregabalin for the first 3 days, then 300 mg/day for a further 2 days. The second group received a placebo for the same length of time. Patient headaches were scored using the visual analog scale, and diclofenac sodium and pethidine requirements were recorded. Relative to the placebo group, the group administered pregabalin had significantly lower visual analog scale scores after the second day of treatment, and had significantly lower diclofenac sodium requirements. Our results indicate that pregabalin may be useful for the management of PDPH.
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2011.02.029