Sporadic primary malignant intracerebral nerve sheath tumors: case report and literature review

We report the case of a seventy-five year old woman with a sporadic primary malignant intracerebral nerve sheath tumor (MINST). These tumors fall within the spectrum of malignant peripheral nerve sheath tumors (MPNST) but confirming the diagnosis of a MINST can be difficult due to its rarity and unu...

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Bibliographic Details
Published in:Journal of neuro-oncology 2011-09, Vol.104 (2), p.605-610
Main Authors: Barnard, Zachary Rollins, Agarwalla, Pankaj Kumar, Jeyaretna, Deva Sanjeeva, Farrell, Christopher James, Gerstner, Elizabeth Robins, Tian, Di, Curry, William Thomas
Format: Article
Language:English
Subjects:
Aged
Brain Neoplasms - pathology
Case Report
Diagnosis, Differential
Female
Glioma - pathology
Humans
Immunohistochemistry
Medicine
Medicine & Public Health
Microscopy, Electron, Transmission
Nerve Sheath Neoplasms - pathology
Neurology
Oncology
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Summary:We report the case of a seventy-five year old woman with a sporadic primary malignant intracerebral nerve sheath tumor (MINST). These tumors fall within the spectrum of malignant peripheral nerve sheath tumors (MPNST) but confirming the diagnosis of a MINST can be difficult due to its rarity and unusual intraparenchymal location. Radiographically, MINST’s mimic malignant glioma and should be considered in the differential diagnosis of enhancing cerebral lesions. In this report, we present a comprehensive panel of histological, immunohistochemical, ultrastructural, and genetic considerations that may be used to diagnosis MINST based on their similarities to MPNSTs and brain parenchyma location.
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-011-0531-7