Glioblastoma multiforme with very rapid growth and long-term survival in children: report of two cases and review of the literature

Glioblastoma occurs rarely in pediatric patients (0.6–7.9% of all glioblastomas). Symptom duration is about 3–5 months prior to diagnosis with a dismal prognosis (median survival of 50 weeks). The authors describe two pediatric age patients with histopathologically confirmed glioblastoma multiforme...

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Bibliographic Details
Published in:Child's nervous system 2011-08, Vol.27 (8), p.1347-1352
Main Authors: Khalatbari, Mahmoud Reza, Hamidi, Mehrdokht, Moharamzad, Yashar
Format: Article
Language:English
Subjects:
Antineoplastic Agents - therapeutic use
Brain Neoplasms - mortality
Brain Neoplasms - pathology
Brain Neoplasms - therapy
Case Report
Child
Combined Modality Therapy
Female
Glioblastoma - mortality
Glioblastoma - pathology
Glioblastoma - therapy
Humans
Magnetic Resonance Imaging
Medicine
Medicine & Public Health
Neurosciences
Neurosurgery
Neurosurgical Procedures
Radiotherapy
Tomography, X-Ray Computed
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Summary:Glioblastoma occurs rarely in pediatric patients (0.6–7.9% of all glioblastomas). Symptom duration is about 3–5 months prior to diagnosis with a dismal prognosis (median survival of 50 weeks). The authors describe two pediatric age patients with histopathologically confirmed glioblastoma multiforme whose lesions appeared within just 1 week of normal computed tomography scan and magnetic resonance imaging. Both patients had long-term survival (one of them 6 years and the other 3 years and 7 months) following tumor resection. The present report serially illustrates the very rapid development of glioblastoma in childhood and emphasizes the importance of serial neuroimaging as well as paying attention to sudden onset headaches in pediatric patients with inconclusive imaging findings.
ISSN:0256-7040
1433-0350
DOI:10.1007/s00381-011-1492-z