Parathyroid hormone-related protein and its receptor in human glial tumors

Parathyroid hormone-related protein (PTHrP) and its mRNA have been found to be expressed in a variety of human tumors including breast, prostate, colon, lung, renal and ovarian cancers. The purpose of this study is to evaluate the expression of PTH/PTHrP receptor and ligand in human glial tumors. We...

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Bibliographic Details
Published in:Acta neurochirurgica 2000-01, Vol.142 (8), p.871-878
Main Authors: Evliyaoglu, C, Carroll, R, Folkerth, R, Bello, L, Bruns, D E, Black, P M
Format: Article
Language:English
Subjects:
Adult
Aged
Blotting, Western
Brain Neoplasms - chemistry
Brain Neoplasms - pathology
Female
Gene Expression Regulation, Neoplastic
Glioblastoma - chemistry
Glioma - chemistry
Glioma - pathology
Humans
Immunohistochemistry
Ligands
Male
Middle Aged
Neoplasm Proteins - analysis
Parathyroid Hormone - analysis
Parathyroid Hormone-Related Protein
Proteins - analysis
Proteins - genetics
Receptors, Parathyroid Hormone - analysis
Receptors, Parathyroid Hormone - genetics
Tumor Cells, Cultured
Tumors
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Summary:Parathyroid hormone-related protein (PTHrP) and its mRNA have been found to be expressed in a variety of human tumors including breast, prostate, colon, lung, renal and ovarian cancers. The purpose of this study is to evaluate the expression of PTH/PTHrP receptor and ligand in human glial tumors. We examined the coexpression of PTH/PTHrP receptor and ligand in 73 glial tumors of different histological grades and 4 nonneoplastic human brain specimens and three glioblastoma cell lines, by using Western Blot analysis and immunohistochemical analysis. PTHrP and PTH/PTHrP receptors were shown in the neurons, reactive astrocytes and the endothelial cells of normal brain tissue as well as tumor cells, reactive astrocytes and vasculature of nonneoplastic tissue. They were expressed at higher levels in pure astrocytic tumors as compared to tumors with oligodendroglial components. PTH/PTHrP receptor and PTHrP ligand are co-expressed in human glial tumors. There increased expression suggests an autocrine and/or paracrine loop may exist.
ISSN:0001-6268
0942-0940
DOI:10.1007/s007010070072