Metastatic brain tumours from oesophageal carcinoma: neuro-imaging and clinicopathological characteristics in Japanese patients

• Published in: Acta neurochirurgica 2001-01, Vol.143 (1), p.31-36
• Main Authors: Takeshima, H, Kuratsu, J, Nishi, T, Soyama, N, Miura, M, Masumitsu, T, Ushio, Y
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Brain - pathology; Brain Neoplasms - diagnosis; Brain Neoplasms - pathology; Brain Neoplasms - secondary; Carcinoma, Small Cell - diagnosis; Carcinoma, Small Cell - pathology; Carcinoma, Small Cell - secondary; Carcinoma, Squamous Cell - diagnosis; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - secondary; Esophageal Neoplasms - diagnosis; Esophageal Neoplasms - pathology; Esophagus - pathology; Humans; Japan; Magnetic Resonance Imaging; Male; Middle Aged; Prognosis; Tomography, X-Ray Computed
• ISSN: 0001-6268; 0942-0940
• DOI: 10.1007/s007010170135

Since metastatic brain tumours from esophageal carcinoma are essentially rare, previous reports have not determined the common neuro-radiological findings and its clinical aspects. We report the neuro-imaging and clinicopathological features of our 8 metastatic brain tumours from an esophageal site. Histologically, 6 of our 8 patients had squamous cell carcinoma and 2 had small cell carcinoma, a rare variant form. Both histological types mainly exhibited cystic lesions with a thin enhanced rim on magnetic resonance images (MRI, 4 of 6 squamous cell carcinomas and 1 of 2 small cell carcinomas). Combination therapy (irradiation and chemotherapy) after surgical treatment, the number of metastatic brain tumours, and the interval between their appearance and the diagnosis of the primary lesion could be prognostic factors in our series. Among Japanese, the vast majority of primary esophageal cancers are squamous cell carcinomas. Therefore, MRI findings of a cystic tumour with a thin enhanced rim may alert one to the possibility of a metastatic brain tumour from the esophagus.