Impaired coronary flow reserve in obstructive sleep apnea and its improvement after continuous positive airway pressure therapy: a transthoracic Doppler echocardiographic study

Background It is reported that patients with obstructive sleep apnea syndrome (OSAS) show endothelial dysfunction and that treatment of OSAS by continuous positive airway pressure (CPAP) therapy improves it. Objective In this study we evaluated coronary flow reserve (CFR), which is considered to be...

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Bibliographic Details
Published in:Journal of echocardiography 2011-06, Vol.9 (2), p.59-63
Main Authors: Obase, Kikuko, Okura, Hiroyuki, Mouri, Keiji, Maehama, Tomoko, Hayashida, Akihiro, Watanabe, Nozomi, Neishi, Yoji, Kawamoto, Takahiro, Oka, Mikio, Yoshida, Kiyoshi
Format: Article
Language:English
Subjects:
Apnea
Cardiology
Doppler effect
Echocardiography
Imaging
Medicine
Medicine & Public Health
Original Investigation
Pressure
Radiology
Respiratory tract
Sleep
Sleep disorders
Ultrasound
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Summary:Background It is reported that patients with obstructive sleep apnea syndrome (OSAS) show endothelial dysfunction and that treatment of OSAS by continuous positive airway pressure (CPAP) therapy improves it. Objective In this study we evaluated coronary flow reserve (CFR), which is considered to be affected by coronary microvascular dysfunction, and the change in CFR during treatment of OSAS by CPAP. Methods Eleven patients who were diagnosed as having OSAS by polysomnography (PSG) were studied. Phasic coronary flow velocity was obtained in the left anterior descending coronary artery at baseline and during hyperemic conditions with transthoracic 2D echocardiography. CFR was defined as the ratio of hyperemic to basal mean diastolic velocity. CFR was obtained before and after the initiation of CPAP therapy. Results Coronary flow reserve was decreased (
ISSN:1349-0222
1880-344X
DOI:10.1007/s12574-010-0074-5