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Impaired coronary flow reserve in obstructive sleep apnea and its improvement after continuous positive airway pressure therapy: a transthoracic Doppler echocardiographic study
Background It is reported that patients with obstructive sleep apnea syndrome (OSAS) show endothelial dysfunction and that treatment of OSAS by continuous positive airway pressure (CPAP) therapy improves it. Objective In this study we evaluated coronary flow reserve (CFR), which is considered to be...
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| Published in: | Journal of echocardiography 2011-06, Vol.9 (2), p.59-63 |
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| Main Authors: | , , , , , , , , , |
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| container_end_page | 63 |
| container_issue | 2 |
| container_start_page | 59 |
| container_title | Journal of echocardiography |
| container_volume | 9 |
| creator | Obase, Kikuko Okura, Hiroyuki Mouri, Keiji Maehama, Tomoko Hayashida, Akihiro Watanabe, Nozomi Neishi, Yoji Kawamoto, Takahiro Oka, Mikio Yoshida, Kiyoshi |
| description | Background
It is reported that patients with obstructive sleep apnea syndrome (OSAS) show endothelial dysfunction and that treatment of OSAS by continuous positive airway pressure (CPAP) therapy improves it.
Objective
In this study we evaluated coronary flow reserve (CFR), which is considered to be affected by coronary microvascular dysfunction, and the change in CFR during treatment of OSAS by CPAP.
Methods
Eleven patients who were diagnosed as having OSAS by polysomnography (PSG) were studied. Phasic coronary flow velocity was obtained in the left anterior descending coronary artery at baseline and during hyperemic conditions with transthoracic 2D echocardiography. CFR was defined as the ratio of hyperemic to basal mean diastolic velocity. CFR was obtained before and after the initiation of CPAP therapy.
Results
Coronary flow reserve was decreased ( |
| doi_str_mv | 10.1007/s12574-010-0074-5 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_910652868</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>910652868</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-bbbe0f8e60b43196af7e0e59367467ff834bc11651faf32147833007460018ea3</originalsourceid><addsrcrecordid>eNp9kc2OFSEQhTtG4_zoA7gx7HTTCjR_7c6MOk4yiRtN3BGaLuYy6QYEeib3rXxEud7R5aygUl8dqHO67hXB7wjG8n0hlEvWY4L7VrKeP-lOiVK4Hxj7-bTdBzb2mFJ60p2VcosxFyOVz7sTKqkUSpHT7vfVmozPMCMbcwwm75Fb4j3KUCDfAfIBxanUvNnqW1kWgIRMCmCQCTPytSC_phzvYIVQkXEVcpMK1YctbgWlWPzfyfbIvdmj1ITLlgHVHWST9h-QQTWbUOouZmO9RZ9iSksTAbuL1uTZx5sG7lqn1G3ev-ieObMUePlwnnc_vnz-fvG1v_52eXXx8bq3DPPaT9ME2CkQeGIDGYVxEjDwcRCSCemcGthkCRGcOOMGSphUw3AwUWBMFJjhvHtz1G3L_dqgVL36YmFZTIC2mB4JFpwqoRr59lGSyJErwTk7oOSI2hxLyeB0yn5tpmuC9SFSfYxUt0j14Teat5nXD_LbtML8f-Jfhg2gR6C0VriBrG_jlkMz5xHVP4y5sPk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1795865548</pqid></control><display><type>article</type><title>Impaired coronary flow reserve in obstructive sleep apnea and its improvement after continuous positive airway pressure therapy: a transthoracic Doppler echocardiographic study</title><source>Springer Nature</source><creator>Obase, Kikuko ; Okura, Hiroyuki ; Mouri, Keiji ; Maehama, Tomoko ; Hayashida, Akihiro ; Watanabe, Nozomi ; Neishi, Yoji ; Kawamoto, Takahiro ; Oka, Mikio ; Yoshida, Kiyoshi</creator><creatorcontrib>Obase, Kikuko ; Okura, Hiroyuki ; Mouri, Keiji ; Maehama, Tomoko ; Hayashida, Akihiro ; Watanabe, Nozomi ; Neishi, Yoji ; Kawamoto, Takahiro ; Oka, Mikio ; Yoshida, Kiyoshi</creatorcontrib><description>Background
It is reported that patients with obstructive sleep apnea syndrome (OSAS) show endothelial dysfunction and that treatment of OSAS by continuous positive airway pressure (CPAP) therapy improves it.
Objective
In this study we evaluated coronary flow reserve (CFR), which is considered to be affected by coronary microvascular dysfunction, and the change in CFR during treatment of OSAS by CPAP.
Methods
Eleven patients who were diagnosed as having OSAS by polysomnography (PSG) were studied. Phasic coronary flow velocity was obtained in the left anterior descending coronary artery at baseline and during hyperemic conditions with transthoracic 2D echocardiography. CFR was defined as the ratio of hyperemic to basal mean diastolic velocity. CFR was obtained before and after the initiation of CPAP therapy.
Results
Coronary flow reserve was decreased (<2.5) in 8 of 11 (73%) patients at baseline. After CPAP therapy, CFR of these 8 patients increased significantly.
Conclusion
Coronary flow reserve was decreased in 73% of the patients with OSAS and was significantly improved after CPAP therapy.</description><identifier>ISSN: 1349-0222</identifier><identifier>EISSN: 1880-344X</identifier><identifier>DOI: 10.1007/s12574-010-0074-5</identifier><identifier>PMID: 27276881</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Apnea ; Cardiology ; Doppler effect ; Echocardiography ; Imaging ; Medicine ; Medicine & Public Health ; Original Investigation ; Pressure ; Radiology ; Respiratory tract ; Sleep ; Sleep disorders ; Ultrasound</subject><ispartof>Journal of echocardiography, 2011-06, Vol.9 (2), p.59-63</ispartof><rights>Japanese Society of Echocardiography 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-bbbe0f8e60b43196af7e0e59367467ff834bc11651faf32147833007460018ea3</citedby><cites>FETCH-LOGICAL-c405t-bbbe0f8e60b43196af7e0e59367467ff834bc11651faf32147833007460018ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27276881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Obase, Kikuko</creatorcontrib><creatorcontrib>Okura, Hiroyuki</creatorcontrib><creatorcontrib>Mouri, Keiji</creatorcontrib><creatorcontrib>Maehama, Tomoko</creatorcontrib><creatorcontrib>Hayashida, Akihiro</creatorcontrib><creatorcontrib>Watanabe, Nozomi</creatorcontrib><creatorcontrib>Neishi, Yoji</creatorcontrib><creatorcontrib>Kawamoto, Takahiro</creatorcontrib><creatorcontrib>Oka, Mikio</creatorcontrib><creatorcontrib>Yoshida, Kiyoshi</creatorcontrib><title>Impaired coronary flow reserve in obstructive sleep apnea and its improvement after continuous positive airway pressure therapy: a transthoracic Doppler echocardiographic study</title><title>Journal of echocardiography</title><addtitle>J Echocardiogr</addtitle><addtitle>J Echocardiogr</addtitle><description>Background
It is reported that patients with obstructive sleep apnea syndrome (OSAS) show endothelial dysfunction and that treatment of OSAS by continuous positive airway pressure (CPAP) therapy improves it.
Objective
In this study we evaluated coronary flow reserve (CFR), which is considered to be affected by coronary microvascular dysfunction, and the change in CFR during treatment of OSAS by CPAP.
Methods
Eleven patients who were diagnosed as having OSAS by polysomnography (PSG) were studied. Phasic coronary flow velocity was obtained in the left anterior descending coronary artery at baseline and during hyperemic conditions with transthoracic 2D echocardiography. CFR was defined as the ratio of hyperemic to basal mean diastolic velocity. CFR was obtained before and after the initiation of CPAP therapy.
Results
Coronary flow reserve was decreased (<2.5) in 8 of 11 (73%) patients at baseline. After CPAP therapy, CFR of these 8 patients increased significantly.
Conclusion
Coronary flow reserve was decreased in 73% of the patients with OSAS and was significantly improved after CPAP therapy.</description><subject>Apnea</subject><subject>Cardiology</subject><subject>Doppler effect</subject><subject>Echocardiography</subject><subject>Imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Investigation</subject><subject>Pressure</subject><subject>Radiology</subject><subject>Respiratory tract</subject><subject>Sleep</subject><subject>Sleep disorders</subject><subject>Ultrasound</subject><issn>1349-0222</issn><issn>1880-344X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9kc2OFSEQhTtG4_zoA7gx7HTTCjR_7c6MOk4yiRtN3BGaLuYy6QYEeib3rXxEud7R5aygUl8dqHO67hXB7wjG8n0hlEvWY4L7VrKeP-lOiVK4Hxj7-bTdBzb2mFJ60p2VcosxFyOVz7sTKqkUSpHT7vfVmozPMCMbcwwm75Fb4j3KUCDfAfIBxanUvNnqW1kWgIRMCmCQCTPytSC_phzvYIVQkXEVcpMK1YctbgWlWPzfyfbIvdmj1ITLlgHVHWST9h-QQTWbUOouZmO9RZ9iSksTAbuL1uTZx5sG7lqn1G3ev-ieObMUePlwnnc_vnz-fvG1v_52eXXx8bq3DPPaT9ME2CkQeGIDGYVxEjDwcRCSCemcGthkCRGcOOMGSphUw3AwUWBMFJjhvHtz1G3L_dqgVL36YmFZTIC2mB4JFpwqoRr59lGSyJErwTk7oOSI2hxLyeB0yn5tpmuC9SFSfYxUt0j14Teat5nXD_LbtML8f-Jfhg2gR6C0VriBrG_jlkMz5xHVP4y5sPk</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Obase, Kikuko</creator><creator>Okura, Hiroyuki</creator><creator>Mouri, Keiji</creator><creator>Maehama, Tomoko</creator><creator>Hayashida, Akihiro</creator><creator>Watanabe, Nozomi</creator><creator>Neishi, Yoji</creator><creator>Kawamoto, Takahiro</creator><creator>Oka, Mikio</creator><creator>Yoshida, Kiyoshi</creator><general>Springer Japan</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20110601</creationdate><title>Impaired coronary flow reserve in obstructive sleep apnea and its improvement after continuous positive airway pressure therapy: a transthoracic Doppler echocardiographic study</title><author>Obase, Kikuko ; Okura, Hiroyuki ; Mouri, Keiji ; Maehama, Tomoko ; Hayashida, Akihiro ; Watanabe, Nozomi ; Neishi, Yoji ; Kawamoto, Takahiro ; Oka, Mikio ; Yoshida, Kiyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-bbbe0f8e60b43196af7e0e59367467ff834bc11651faf32147833007460018ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Apnea</topic><topic>Cardiology</topic><topic>Doppler effect</topic><topic>Echocardiography</topic><topic>Imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Investigation</topic><topic>Pressure</topic><topic>Radiology</topic><topic>Respiratory tract</topic><topic>Sleep</topic><topic>Sleep disorders</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Obase, Kikuko</creatorcontrib><creatorcontrib>Okura, Hiroyuki</creatorcontrib><creatorcontrib>Mouri, Keiji</creatorcontrib><creatorcontrib>Maehama, Tomoko</creatorcontrib><creatorcontrib>Hayashida, Akihiro</creatorcontrib><creatorcontrib>Watanabe, Nozomi</creatorcontrib><creatorcontrib>Neishi, Yoji</creatorcontrib><creatorcontrib>Kawamoto, Takahiro</creatorcontrib><creatorcontrib>Oka, Mikio</creatorcontrib><creatorcontrib>Yoshida, Kiyoshi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of echocardiography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Obase, Kikuko</au><au>Okura, Hiroyuki</au><au>Mouri, Keiji</au><au>Maehama, Tomoko</au><au>Hayashida, Akihiro</au><au>Watanabe, Nozomi</au><au>Neishi, Yoji</au><au>Kawamoto, Takahiro</au><au>Oka, Mikio</au><au>Yoshida, Kiyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired coronary flow reserve in obstructive sleep apnea and its improvement after continuous positive airway pressure therapy: a transthoracic Doppler echocardiographic study</atitle><jtitle>Journal of echocardiography</jtitle><stitle>J Echocardiogr</stitle><addtitle>J Echocardiogr</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>9</volume><issue>2</issue><spage>59</spage><epage>63</epage><pages>59-63</pages><issn>1349-0222</issn><eissn>1880-344X</eissn><abstract>Background
It is reported that patients with obstructive sleep apnea syndrome (OSAS) show endothelial dysfunction and that treatment of OSAS by continuous positive airway pressure (CPAP) therapy improves it.
Objective
In this study we evaluated coronary flow reserve (CFR), which is considered to be affected by coronary microvascular dysfunction, and the change in CFR during treatment of OSAS by CPAP.
Methods
Eleven patients who were diagnosed as having OSAS by polysomnography (PSG) were studied. Phasic coronary flow velocity was obtained in the left anterior descending coronary artery at baseline and during hyperemic conditions with transthoracic 2D echocardiography. CFR was defined as the ratio of hyperemic to basal mean diastolic velocity. CFR was obtained before and after the initiation of CPAP therapy.
Results
Coronary flow reserve was decreased (<2.5) in 8 of 11 (73%) patients at baseline. After CPAP therapy, CFR of these 8 patients increased significantly.
Conclusion
Coronary flow reserve was decreased in 73% of the patients with OSAS and was significantly improved after CPAP therapy.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>27276881</pmid><doi>10.1007/s12574-010-0074-5</doi><tpages>5</tpages></addata></record> |
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| language | eng |
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| source | Springer Nature |
| subjects | Apnea Cardiology Doppler effect Echocardiography Imaging Medicine Medicine & Public Health Original Investigation Pressure Radiology Respiratory tract Sleep Sleep disorders Ultrasound |
| title | Impaired coronary flow reserve in obstructive sleep apnea and its improvement after continuous positive airway pressure therapy: a transthoracic Doppler echocardiographic study |
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