Age at onset in multiple sclerosis

Age at onset of multiple sclerosis (MS) can vary from childhood to adult life. Many reports have been carried out over the years concerning the role of age at onset in determining the disease outcome. In a sporadic MS population of 1463 patients with homogeneous clinical and demographic features, de...

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Published in:Neurological sciences 2000-12, Vol.21 (4 Suppl 2), p.S825-S829
Main Authors: Liguori, M, Marrosu, M G, Pugliatti, M, Giuliani, F, De Robertis, F, Cocco, E, Zimatore, G B, Livrea, P, Trojano, M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Distribution
Age of Onset
Aged
Analysis of Variance
Child
Cohort Studies
Disease Progression
Female
Humans
Italy - epidemiology
Male
Medical research
Middle Aged
Multiple Sclerosis - epidemiology
Multiple Sclerosis - physiopathology
Neurosciences
Prognosis
Sex Factors
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cited_by cdi_FETCH-LOGICAL-c1957-7e13b8c9942943cef6b702582d8d2545d632b3a5f6c941a0c49e35fbcd2c72863
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container_end_page S829
container_issue 4 Suppl 2
container_start_page S825
container_title Neurological sciences
container_volume 21
creator Liguori, M
Marrosu, M G
Pugliatti, M
Giuliani, F
De Robertis, F
Cocco, E
Zimatore, G B
Livrea, P
Trojano, M
description Age at onset of multiple sclerosis (MS) can vary from childhood to adult life. Many reports have been carried out over the years concerning the role of age at onset in determining the disease outcome. In a sporadic MS population of 1463 patients with homogeneous clinical and demographic features, derived from three Italian neurological centres (Bari, Cagliari and Sassari), we analysed the relative weights of current age and age at onset on disease severity according to the expanded disability status scale (EDSS) score, by fixing the disease duration. The results of present study demonstrate that clinical disability in MS is influenced by the patient's age (p < 0.01) and not by the age at onset. Therefore, these data do not confirm the hypothesis that an early age at onset should be considered a favourable prognostic factor of the disease outcome.
doi_str_mv 10.1007/s100720070020
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source Springer Nature
subjects Adolescent
Adult
Age Distribution
Age of Onset
Aged
Analysis of Variance
Child
Cohort Studies
Disease Progression
Female
Humans
Italy - epidemiology
Male
Medical research
Middle Aged
Multiple Sclerosis - epidemiology
Multiple Sclerosis - physiopathology
Neurosciences
Prognosis
Sex Factors
title Age at onset in multiple sclerosis
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