Parkinsonism in a patient with AIDS and cerebral opportunistic granulomatous lesions

The localization of opportunistic infections in the basal ganglia in patients with acquired immunodeficiency syndrome (AIDS) can cause movement disorders, such as choreoathetosis, dystonia, hemiballism and, more rarely, parkinsonism. We describe the case of an AIDS patient who developed cerebral opp...

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Bibliographic Details
Published in:Neurological sciences 2000-06, Vol.21 (3), p.173-176
Main Authors: Maggi, P, de Mari, M, Moramarco, A, Fiorentino, G, Lamberti, P, Angarano, G
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
AIDS-Related Opportunistic Infections - complications
AIDS-Related Opportunistic Infections - parasitology
Basal ganglia
Central nervous system diseases
Choreoathetosis
Dystonia
Fatal Outcome
Granuloma - parasitology
HIV
Human immunodeficiency virus
Humans
Immunodeficiency
Magnetic Resonance Imaging
Male
Movement disorders
Neurosciences
Neurotoxicity
Opportunist infection
Parkinson Disease - parasitology
Parkinson Disease - virology
Toxoplasmosis, Cerebral - complications
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Summary:The localization of opportunistic infections in the basal ganglia in patients with acquired immunodeficiency syndrome (AIDS) can cause movement disorders, such as choreoathetosis, dystonia, hemiballism and, more rarely, parkinsonism. We describe the case of an AIDS patient who developed cerebral opportunistic granulomatous lesions and, subsequently, a parkinsonian akinetic-rigid syndrome. In agreement with cases reported in the literature, the parkinsonian syndrome developed only when the lesions bilaterally involved basal ganglia. The critical localization of the opportunistic lesions in the direct and indirect strio-pallidal pathways possibly associated with the HIV-related neurotoxicity might have contributed to determine this clinical picture.
ISSN:1590-1874
1590-3478
DOI:10.1007/s100720070093