Arabidopsis kinome: after the casting

Arabidopsis thaliana is used as a favourite experimental organism for many aspects of plant biology. We capitalized on the recently available Arabidopsis genome sequence and predicted proteome, to draw up a genome-scale protein serine/threonine kinase (PSTK) inventory. The PSTKs represent about 4% o...

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Bibliographic Details
Published in:Functional & integrative genomics 2004-07, Vol.4 (3), p.163-187
Main Authors: CHAMPION, A, KREIS, M, MOCKAITIS, K, PICAUD, A, HENRY, Y
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Arabidopsis - enzymology
Arabidopsis - genetics
Arabidopsis thaliana
Biological and medical sciences
Catalytic Domain
Classification
Enzymes
Evolution, Molecular
Flowers & plants
Fundamental and applied biological sciences. Psychology
Genes
Genetics
Genomics
Microbiology
Miscellaneous
Phylogeny
Protein-Serine-Threonine Kinases - chemistry
Protein-Serine-Threonine Kinases - genetics
Proteins
Substrate Specificity
Virology
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Summary:Arabidopsis thaliana is used as a favourite experimental organism for many aspects of plant biology. We capitalized on the recently available Arabidopsis genome sequence and predicted proteome, to draw up a genome-scale protein serine/threonine kinase (PSTK) inventory. The PSTKs represent about 4% of the A. thaliana proteome. In this study, we provide a description of the content and diversity of the non-receptor PSTKs. These kinases have crucial functions in sensing, mediating and coordinating cellular responses to an extensive range of stimuli. A total of 369 predicted non receptor PSTKs were detailed: the Raf superfamily, the CMGC, CaMK, AGC and STE families, as well as a few small clades and orphan sequences. An extensive relationship analysis of these kinases allows us to classify the proteins in superfamilies, families, sub-families and groups. The classification provides a better knowledge of the characteristics shared by the different clades. We focused on the MAP kinase module elements, with particular attention to their docking sites for protein-protein interaction and their biological function. The large number of A. thaliana genes encoding kinases might have been achieved through successive rounds of gene and genome duplications. The evolution towards an increasing gene number suggests that functional redundancy plays an important role in plant genetic robustness.
ISSN:1438-793X
1438-7948
DOI:10.1007/s10142-003-0096-4