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Clinical features and microsurgical treatment of pediatric patients with cerebral cavernous malformation
Abstract The aim of the present study was to describe the clinical features and to evaluate the surgical treatment outcomes of pediatric patients with cerebral cavernous malformations (CCM). We investigated 85 children (53 boys and 32 girls), aged from 6 months to 17.9 years with CCM. Seizures and s...
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Published in: | Journal of clinical neuroscience 2011-10, Vol.18 (10), p.1303-1307 |
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description | Abstract The aim of the present study was to describe the clinical features and to evaluate the surgical treatment outcomes of pediatric patients with cerebral cavernous malformations (CCM). We investigated 85 children (53 boys and 32 girls), aged from 6 months to 17.9 years with CCM. Seizures and symptomatic hemorrhages, which were the most frequent symptoms, occurred in 81 patients. Nine patients had a positive family history of CCM. Eighty patients underwent microsurgical treatment after strict operative indications were met. Neuronavigation, combined with intraoperative ultrasonography or functional MRI, was used for precise localization of the lesions. The principles of minimally invasive techniques were followed during surgery. A total of 89 lesions were removed in 80 patients, and there were no deaths. During their hospital stay, only nine patients suffered from postoperative seizures, which were controlled with medication. Postoperative neurological deficits improved in 27 patients, were unchanged in nine, and worsened in two. With the help of advanced neuroimaging, a satisfactory surgical outcome was achieved for 10 lesions located in eloquent brain areas and four lesions in the brain stem. A follow-up study of 66 patients showed that all of these patients remained seizure-free, and nine patients with postoperative neurological deficits gradually recovered. Microsurgical treatment should be performed early for pediatric patients with CCM. Accurate localization of the lesions and the use of minimally invasive techniques and functional MRI monitoring were the key features of the surgical procedures. |
doi_str_mv | 10.1016/j.jocn.2011.01.033 |
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We investigated 85 children (53 boys and 32 girls), aged from 6 months to 17.9 years with CCM. Seizures and symptomatic hemorrhages, which were the most frequent symptoms, occurred in 81 patients. Nine patients had a positive family history of CCM. Eighty patients underwent microsurgical treatment after strict operative indications were met. Neuronavigation, combined with intraoperative ultrasonography or functional MRI, was used for precise localization of the lesions. The principles of minimally invasive techniques were followed during surgery. A total of 89 lesions were removed in 80 patients, and there were no deaths. During their hospital stay, only nine patients suffered from postoperative seizures, which were controlled with medication. Postoperative neurological deficits improved in 27 patients, were unchanged in nine, and worsened in two. With the help of advanced neuroimaging, a satisfactory surgical outcome was achieved for 10 lesions located in eloquent brain areas and four lesions in the brain stem. A follow-up study of 66 patients showed that all of these patients remained seizure-free, and nine patients with postoperative neurological deficits gradually recovered. Microsurgical treatment should be performed early for pediatric patients with CCM. Accurate localization of the lesions and the use of minimally invasive techniques and functional MRI monitoring were the key features of the surgical procedures.</description><identifier>ISSN: 0967-5868</identifier><identifier>EISSN: 1532-2653</identifier><identifier>DOI: 10.1016/j.jocn.2011.01.033</identifier><identifier>PMID: 21795052</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>Adolescent ; Brain ; Cavernous malformation ; Cavernous Sinus - abnormalities ; Cavernous Sinus - surgery ; Central Nervous System Vascular Malformations - diagnosis ; Central Nervous System Vascular Malformations - surgery ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Humans ; Infant ; Male ; Microsurgery ; Microsurgery - methods ; Neurology ; Treatment Outcome</subject><ispartof>Journal of clinical neuroscience, 2011-10, Vol.18 (10), p.1303-1307</ispartof><rights>Elsevier Ltd</rights><rights>2011 Elsevier Ltd</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-69de83263e63d7e036eb2467999704b3fefcd28b58d509c0212578826699b77b3</citedby><cites>FETCH-LOGICAL-c442t-69de83263e63d7e036eb2467999704b3fefcd28b58d509c0212578826699b77b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21795052$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Jianping</creatorcontrib><creatorcontrib>Qiao, Nidan</creatorcontrib><creatorcontrib>Xie, Liqian</creatorcontrib><creatorcontrib>Qiu, Tianming</creatorcontrib><creatorcontrib>Li, Peiliang</creatorcontrib><creatorcontrib>Wu, Jingsong</creatorcontrib><creatorcontrib>Zhu, Wei</creatorcontrib><creatorcontrib>Chen, Liang</creatorcontrib><creatorcontrib>He, Kang Min</creatorcontrib><creatorcontrib>Zhang, Nan</creatorcontrib><creatorcontrib>Mao, Ying</creatorcontrib><creatorcontrib>Zhao, Yao</creatorcontrib><title>Clinical features and microsurgical treatment of pediatric patients with cerebral cavernous malformation</title><title>Journal of clinical neuroscience</title><addtitle>J Clin Neurosci</addtitle><description>Abstract The aim of the present study was to describe the clinical features and to evaluate the surgical treatment outcomes of pediatric patients with cerebral cavernous malformations (CCM). We investigated 85 children (53 boys and 32 girls), aged from 6 months to 17.9 years with CCM. Seizures and symptomatic hemorrhages, which were the most frequent symptoms, occurred in 81 patients. Nine patients had a positive family history of CCM. Eighty patients underwent microsurgical treatment after strict operative indications were met. Neuronavigation, combined with intraoperative ultrasonography or functional MRI, was used for precise localization of the lesions. The principles of minimally invasive techniques were followed during surgery. A total of 89 lesions were removed in 80 patients, and there were no deaths. During their hospital stay, only nine patients suffered from postoperative seizures, which were controlled with medication. Postoperative neurological deficits improved in 27 patients, were unchanged in nine, and worsened in two. With the help of advanced neuroimaging, a satisfactory surgical outcome was achieved for 10 lesions located in eloquent brain areas and four lesions in the brain stem. A follow-up study of 66 patients showed that all of these patients remained seizure-free, and nine patients with postoperative neurological deficits gradually recovered. Microsurgical treatment should be performed early for pediatric patients with CCM. Accurate localization of the lesions and the use of minimally invasive techniques and functional MRI monitoring were the key features of the surgical procedures.</description><subject>Adolescent</subject><subject>Brain</subject><subject>Cavernous malformation</subject><subject>Cavernous Sinus - abnormalities</subject><subject>Cavernous Sinus - surgery</subject><subject>Central Nervous System Vascular Malformations - diagnosis</subject><subject>Central Nervous System Vascular Malformations - surgery</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Microsurgery</subject><subject>Microsurgery - methods</subject><subject>Neurology</subject><subject>Treatment Outcome</subject><issn>0967-5868</issn><issn>1532-2653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFkkGL1TAQx4Mo7tvVL-BBcvPU5yRpkgZEkIeuwoIH9RzSdOqmts0zaVf225v6nh48KAQCmd8M4fcfQp4x2DNg6uWwH6Kf9xwY20M5QjwgOyYFr7iS4iHZgVG6ko1qLshlzgMAmFrAY3LBmTYSJN-R28MY5uDdSHt0y5owUzd3dAo-xbymr79KSyq1CeeFxp4esQtuScHTo1tCecz0R1huqceEbSq0d3eY5rhmOrmxj2kqWJyfkEe9GzM-Pd9X5Mu7t58P76ubj9cfDm9uKl_XfKmU6bARXAlUotMIQmHLa6WNMRrqVvTY-443rWw6CcYDZ1zqpuFKGdNq3Yor8uI095ji9xXzYqeQPY6jm7H8yRoG2jAu-H_JppFS1bWGQvITuUnJCXt7TGFy6d4ysFsUdrBbFHaLwkI5QpSm5-fxazth96flt_sCvDoBWHTcBUw2--LTF78J_WK7GP49__Vf7f4c5Te8xzzENc1FtGU2cwv207YM2y4wBsWaFOInzhqv8Q</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Song, Jianping</creator><creator>Qiao, Nidan</creator><creator>Xie, Liqian</creator><creator>Qiu, Tianming</creator><creator>Li, Peiliang</creator><creator>Wu, Jingsong</creator><creator>Zhu, Wei</creator><creator>Chen, Liang</creator><creator>He, Kang Min</creator><creator>Zhang, Nan</creator><creator>Mao, Ying</creator><creator>Zhao, Yao</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20111001</creationdate><title>Clinical features and microsurgical treatment of pediatric patients with cerebral cavernous malformation</title><author>Song, Jianping ; Qiao, Nidan ; Xie, Liqian ; Qiu, Tianming ; Li, Peiliang ; Wu, Jingsong ; Zhu, Wei ; Chen, Liang ; He, Kang Min ; Zhang, Nan ; Mao, Ying ; Zhao, Yao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-69de83263e63d7e036eb2467999704b3fefcd28b58d509c0212578826699b77b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Brain</topic><topic>Cavernous malformation</topic><topic>Cavernous Sinus - abnormalities</topic><topic>Cavernous Sinus - surgery</topic><topic>Central Nervous System Vascular Malformations - diagnosis</topic><topic>Central Nervous System Vascular Malformations - surgery</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Microsurgery</topic><topic>Microsurgery - methods</topic><topic>Neurology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Jianping</creatorcontrib><creatorcontrib>Qiao, Nidan</creatorcontrib><creatorcontrib>Xie, Liqian</creatorcontrib><creatorcontrib>Qiu, Tianming</creatorcontrib><creatorcontrib>Li, Peiliang</creatorcontrib><creatorcontrib>Wu, Jingsong</creatorcontrib><creatorcontrib>Zhu, Wei</creatorcontrib><creatorcontrib>Chen, Liang</creatorcontrib><creatorcontrib>He, Kang Min</creatorcontrib><creatorcontrib>Zhang, Nan</creatorcontrib><creatorcontrib>Mao, Ying</creatorcontrib><creatorcontrib>Zhao, Yao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of clinical neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Jianping</au><au>Qiao, Nidan</au><au>Xie, Liqian</au><au>Qiu, Tianming</au><au>Li, Peiliang</au><au>Wu, Jingsong</au><au>Zhu, Wei</au><au>Chen, Liang</au><au>He, Kang Min</au><au>Zhang, Nan</au><au>Mao, Ying</au><au>Zhao, Yao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical features and microsurgical treatment of pediatric patients with cerebral cavernous malformation</atitle><jtitle>Journal of clinical neuroscience</jtitle><addtitle>J Clin Neurosci</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>18</volume><issue>10</issue><spage>1303</spage><epage>1307</epage><pages>1303-1307</pages><issn>0967-5868</issn><eissn>1532-2653</eissn><abstract>Abstract The aim of the present study was to describe the clinical features and to evaluate the surgical treatment outcomes of pediatric patients with cerebral cavernous malformations (CCM). We investigated 85 children (53 boys and 32 girls), aged from 6 months to 17.9 years with CCM. Seizures and symptomatic hemorrhages, which were the most frequent symptoms, occurred in 81 patients. Nine patients had a positive family history of CCM. Eighty patients underwent microsurgical treatment after strict operative indications were met. Neuronavigation, combined with intraoperative ultrasonography or functional MRI, was used for precise localization of the lesions. The principles of minimally invasive techniques were followed during surgery. A total of 89 lesions were removed in 80 patients, and there were no deaths. During their hospital stay, only nine patients suffered from postoperative seizures, which were controlled with medication. Postoperative neurological deficits improved in 27 patients, were unchanged in nine, and worsened in two. With the help of advanced neuroimaging, a satisfactory surgical outcome was achieved for 10 lesions located in eloquent brain areas and four lesions in the brain stem. A follow-up study of 66 patients showed that all of these patients remained seizure-free, and nine patients with postoperative neurological deficits gradually recovered. Microsurgical treatment should be performed early for pediatric patients with CCM. Accurate localization of the lesions and the use of minimally invasive techniques and functional MRI monitoring were the key features of the surgical procedures.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>21795052</pmid><doi>10.1016/j.jocn.2011.01.033</doi><tpages>5</tpages></addata></record> |
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subjects | Adolescent Brain Cavernous malformation Cavernous Sinus - abnormalities Cavernous Sinus - surgery Central Nervous System Vascular Malformations - diagnosis Central Nervous System Vascular Malformations - surgery Child Child, Preschool Female Follow-Up Studies Humans Infant Male Microsurgery Microsurgery - methods Neurology Treatment Outcome |
title | Clinical features and microsurgical treatment of pediatric patients with cerebral cavernous malformation |
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