Characterization of two functional glucocorticoid receptors in the marine medaka Oryzias dancena

Highlights ► Medaka GR2 is more sensitive in responding to cortisol and dexamethasone (DEX) than GR1. ► Aldosterone is a weaker agonist for medaka GR2 compared to cortisol and DEX. ► Although RU486 inhibited transactivation in both GRs, GR2 was more resistant. ► Mammalian coregulators, GRIP-1 and SM...

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Bibliographic Details
Published in:General and comparative endocrinology 2011-05, Vol.171 (3), p.341-349
Main Authors: Kim, Mi Ae, Kim, Dong Soo, Sohn, Young Chang
Format: Article
Language:English
Subjects:
agonists
aldosterone
Amino Acid Sequence
amino acids
Animals
complementary DNA
Coregulator
cortisol
dexamethasone
Dexamethasone - pharmacology
Endocrinology & Metabolism
euryhaline species
fish
Freshwater
Glucocorticoid receptors
Hormone Antagonists - pharmacology
Hydrocortisone - pharmacology
Marine
Medaka
Mifepristone - pharmacology
Molecular Sequence Data
open reading frames
Oryzias
Oryzias - metabolism
Oryzias dancena
Oryzias latipes
phylogeny
Receptors, Glucocorticoid - antagonists & inhibitors
Receptors, Glucocorticoid - drug effects
Receptors, Glucocorticoid - metabolism
reporter genes
RNA, Messenger - genetics
sequence analysis
Sequence Homology, Amino Acid
Teleost
Teleostei
transcription (genetics)
transcriptional activation
transfection
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Summary:Highlights ► Medaka GR2 is more sensitive in responding to cortisol and dexamethasone (DEX) than GR1. ► Aldosterone is a weaker agonist for medaka GR2 compared to cortisol and DEX. ► Although RU486 inhibited transactivation in both GRs, GR2 was more resistant. ► Mammalian coregulators, GRIP-1 and SMILE, modulate agonist-activated medaka GR1 and GR2. ► Medaka GR2 is a functionally closer ortholog to mammalian GRα.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2011.02.015