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Characterization of two functional glucocorticoid receptors in the marine medaka Oryzias dancena
Highlights ► Medaka GR2 is more sensitive in responding to cortisol and dexamethasone (DEX) than GR1. ► Aldosterone is a weaker agonist for medaka GR2 compared to cortisol and DEX. ► Although RU486 inhibited transactivation in both GRs, GR2 was more resistant. ► Mammalian coregulators, GRIP-1 and SM...
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| Published in: | General and comparative endocrinology 2011-05, Vol.171 (3), p.341-349 |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c535t-db72475833b906e072f90b50be9f7a51940eb49cd6ffd47f05d4853e7ef4c9c53 |
| container_end_page | 349 |
| container_issue | 3 |
| container_start_page | 341 |
| container_title | General and comparative endocrinology |
| container_volume | 171 |
| creator | Kim, Mi Ae Kim, Dong Soo Sohn, Young Chang |
| description | Highlights ► Medaka GR2 is more sensitive in responding to cortisol and dexamethasone (DEX) than GR1. ► Aldosterone is a weaker agonist for medaka GR2 compared to cortisol and DEX. ► Although RU486 inhibited transactivation in both GRs, GR2 was more resistant. ► Mammalian coregulators, GRIP-1 and SMILE, modulate agonist-activated medaka GR1 and GR2. ► Medaka GR2 is a functionally closer ortholog to mammalian GRα. |
| doi_str_mv | 10.1016/j.ygcen.2011.02.015 |
| format | article |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c535t-db72475833b906e072f90b50be9f7a51940eb49cd6ffd47f05d4853e7ef4c9c53</citedby><cites>FETCH-LOGICAL-c535t-db72475833b906e072f90b50be9f7a51940eb49cd6ffd47f05d4853e7ef4c9c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21362423$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Mi Ae</creatorcontrib><creatorcontrib>Kim, Dong Soo</creatorcontrib><creatorcontrib>Sohn, Young Chang</creatorcontrib><title>Characterization of two functional glucocorticoid receptors in the marine medaka Oryzias dancena</title><title>General and comparative endocrinology</title><addtitle>Gen Comp Endocrinol</addtitle><description>Highlights ► Medaka GR2 is more sensitive in responding to cortisol and dexamethasone (DEX) than GR1. ► Aldosterone is a weaker agonist for medaka GR2 compared to cortisol and DEX. ► Although RU486 inhibited transactivation in both GRs, GR2 was more resistant. ► Mammalian coregulators, GRIP-1 and SMILE, modulate agonist-activated medaka GR1 and GR2. ► Medaka GR2 is a functionally closer ortholog to mammalian GRα.</description><subject>agonists</subject><subject>aldosterone</subject><subject>Amino Acid Sequence</subject><subject>amino acids</subject><subject>Animals</subject><subject>complementary DNA</subject><subject>Coregulator</subject><subject>cortisol</subject><subject>dexamethasone</subject><subject>Dexamethasone - pharmacology</subject><subject>Endocrinology & Metabolism</subject><subject>euryhaline species</subject><subject>fish</subject><subject>Freshwater</subject><subject>Glucocorticoid receptors</subject><subject>Hormone Antagonists - pharmacology</subject><subject>Hydrocortisone - pharmacology</subject><subject>Marine</subject><subject>Medaka</subject><subject>Mifepristone - pharmacology</subject><subject>Molecular Sequence Data</subject><subject>open reading frames</subject><subject>Oryzias</subject><subject>Oryzias - metabolism</subject><subject>Oryzias dancena</subject><subject>Oryzias latipes</subject><subject>phylogeny</subject><subject>Receptors, Glucocorticoid - antagonists & inhibitors</subject><subject>Receptors, Glucocorticoid - drug effects</subject><subject>Receptors, Glucocorticoid - metabolism</subject><subject>reporter genes</subject><subject>RNA, Messenger - genetics</subject><subject>sequence analysis</subject><subject>Sequence Homology, Amino Acid</subject><subject>Teleost</subject><subject>Teleostei</subject><subject>transcription (genetics)</subject><subject>transcriptional activation</subject><subject>transfection</subject><issn>0016-6480</issn><issn>1095-6840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFks1u1DAUhS0EokPhCZDAO1YT7PgvWYCERkArVeqidG0c53rqaRoPdgKaPj03TGHBpivL0neOr8-5hLzmrOKM6_e76rD1MFY147xidcW4ekJWnLVqrRvJnpIVQ2ytZcNOyItSdowxJTR_Tk5qLnQta7Ei3zc3Ljs_QY73bopppCnQ6VeiYR79cncD3Q6zTz7lKfoUe5rBw35KudA40ukG6J3LccQDenfr6GU-3EdXaO9GnM69JM-CGwq8ejhPyfWXz982Z-uLy6_nm08Xa6-EmtZ9Z2ppVCNE1zINzNShZZ1iHbTBOMVbyaCTre91CL00galeNkqAgSB9ix6n5N3Rd5_TjxnKZO9i8TAMboQ0F9tyzhUmJR8lG80NPqc5kuJI-pxKyRDsPkf87cFyZpcO7M7-6cAuHVhWW-wAVW8e_OcOM_mn-Rs6Am-PQHDJum2OxV5foYPCvoTRpkbiw5EATOxnhGyLj4B59hHTn2yf4iMjfPxP74c4Ru-GWzhA2aU5Y7HFcltQYK-WRVn2hHPcEa2M-A0GBreS</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Kim, Mi Ae</creator><creator>Kim, Dong Soo</creator><creator>Sohn, Young Chang</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TN</scope><scope>7TS</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope></search><sort><creationdate>20110501</creationdate><title>Characterization of two functional glucocorticoid receptors in the marine medaka Oryzias dancena</title><author>Kim, Mi Ae ; Kim, Dong Soo ; Sohn, Young Chang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c535t-db72475833b906e072f90b50be9f7a51940eb49cd6ffd47f05d4853e7ef4c9c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>agonists</topic><topic>aldosterone</topic><topic>Amino Acid Sequence</topic><topic>amino acids</topic><topic>Animals</topic><topic>complementary DNA</topic><topic>Coregulator</topic><topic>cortisol</topic><topic>dexamethasone</topic><topic>Dexamethasone - pharmacology</topic><topic>Endocrinology & Metabolism</topic><topic>euryhaline species</topic><topic>fish</topic><topic>Freshwater</topic><topic>Glucocorticoid receptors</topic><topic>Hormone Antagonists - pharmacology</topic><topic>Hydrocortisone - pharmacology</topic><topic>Marine</topic><topic>Medaka</topic><topic>Mifepristone - pharmacology</topic><topic>Molecular Sequence Data</topic><topic>open reading frames</topic><topic>Oryzias</topic><topic>Oryzias - metabolism</topic><topic>Oryzias dancena</topic><topic>Oryzias latipes</topic><topic>phylogeny</topic><topic>Receptors, Glucocorticoid - antagonists & inhibitors</topic><topic>Receptors, Glucocorticoid - drug effects</topic><topic>Receptors, Glucocorticoid - metabolism</topic><topic>reporter genes</topic><topic>RNA, Messenger - genetics</topic><topic>sequence analysis</topic><topic>Sequence Homology, Amino Acid</topic><topic>Teleost</topic><topic>Teleostei</topic><topic>transcription (genetics)</topic><topic>transcriptional activation</topic><topic>transfection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Mi Ae</creatorcontrib><creatorcontrib>Kim, Dong Soo</creatorcontrib><creatorcontrib>Sohn, Young Chang</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Oceanic Abstracts</collection><collection>Physical Education Index</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>General and comparative endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Mi Ae</au><au>Kim, Dong Soo</au><au>Sohn, Young Chang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of two functional glucocorticoid receptors in the marine medaka Oryzias dancena</atitle><jtitle>General and comparative endocrinology</jtitle><addtitle>Gen Comp Endocrinol</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>171</volume><issue>3</issue><spage>341</spage><epage>349</epage><pages>341-349</pages><issn>0016-6480</issn><eissn>1095-6840</eissn><abstract>Highlights ► Medaka GR2 is more sensitive in responding to cortisol and dexamethasone (DEX) than GR1. ► Aldosterone is a weaker agonist for medaka GR2 compared to cortisol and DEX. ► Although RU486 inhibited transactivation in both GRs, GR2 was more resistant. ► Mammalian coregulators, GRIP-1 and SMILE, modulate agonist-activated medaka GR1 and GR2. ► Medaka GR2 is a functionally closer ortholog to mammalian GRα.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21362423</pmid><doi>10.1016/j.ygcen.2011.02.015</doi><tpages>9</tpages></addata></record> |
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| source | ScienceDirect Journals |
| subjects | agonists aldosterone Amino Acid Sequence amino acids Animals complementary DNA Coregulator cortisol dexamethasone Dexamethasone - pharmacology Endocrinology & Metabolism euryhaline species fish Freshwater Glucocorticoid receptors Hormone Antagonists - pharmacology Hydrocortisone - pharmacology Marine Medaka Mifepristone - pharmacology Molecular Sequence Data open reading frames Oryzias Oryzias - metabolism Oryzias dancena Oryzias latipes phylogeny Receptors, Glucocorticoid - antagonists & inhibitors Receptors, Glucocorticoid - drug effects Receptors, Glucocorticoid - metabolism reporter genes RNA, Messenger - genetics sequence analysis Sequence Homology, Amino Acid Teleost Teleostei transcription (genetics) transcriptional activation transfection |
| title | Characterization of two functional glucocorticoid receptors in the marine medaka Oryzias dancena |
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