Antihepatotoxic activity of Saussurea lappa extract on D-galactosamine and lipopolysaccharide-induced hepatitis in mice

The effects of aqueous-methanol extract of Saussurea lappa Clarke root (Sl.Cr) was investigated against D-galactosamine (D-GalN) and lipopolysaccharide (LPS)-induced hepatitis in mice. Co-administration of D-GalN (700 mg/kg) and LPS (1 μg/kg) significantly raised the plasma transaminase levels (ALT/...

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Bibliographic Details
Published in:Phytotherapy research 2010-06, Vol.24 (S2), p.S229-S232
Main Authors: Yaeesh, Sheikh, Jamal, Qamar, Shah, Abdul Jabbar, Gilani, Anwarul Hassan
Format: Article
Language:English
Subjects:
Alanine Transaminase - blood
Animals
antihepatotoxic
Apoptosis
Chemical and Drug Induced Liver Injury - drug therapy
D-Galactosamine
Data processing
Enzymes
Female
Galactosamine - toxicity
Hepatitis
hepatoprotective
lipopolysaccharide
lipopolysaccharide, hepatoprotective
Lipopolysaccharides
Lipopolysaccharides - toxicity
Liver
Liver - drug effects
Liver - pathology
Liver diseases
Male
Mice
Mice, Inbred BALB C
Parenchyma
Phytotherapy
Plant Extracts - pharmacology
Plant Roots - chemistry
Plasma levels
Protective Agents - pharmacology
Roots
Saussurea
Saussurea - chemistry
Saussurea lappa
Toxicity Tests, Acute
Toxins
transaminase
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Summary:The effects of aqueous-methanol extract of Saussurea lappa Clarke root (Sl.Cr) was investigated against D-galactosamine (D-GalN) and lipopolysaccharide (LPS)-induced hepatitis in mice. Co-administration of D-GalN (700 mg/kg) and LPS (1 μg/kg) significantly raised the plasma transaminase levels (ALT/AST) as compared to the control group (p < 0.05). Pretreatment of mice with different doses of Sl.Cr (150, 300 and 600 mg/kg) significantly prevented the D-GalN and LPS-induced rise in plasma levels of ALT and AST in a dose-dependent manner (p < 0.05). Post-treatment with Sl.Cr (600 mg/kg) significantly restricted the progression of hepatic damage induced by D-GalN and LPS (p < 0.05). The improvement in plasma enzyme levels was further verified by histopathology of the liver, which showed improved architecture, absence of parenchyma congestion, decreased cellular swelling and apoptotic cells in treatment groups as compared to the toxin group of animals. These data indicate that the Sl.Cr exhibits hepatoprotective effect in mice and this study rationalize the traditional use of this plant in liver disorders. Copyright © 2009 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
1099-1573
DOI:10.1002/ptr.3089