Serial measurements of mesothelin and osteopontin in formerly asbestos exposed power industry workers

Objectives For the proposed tumour markers mesothelin and osteopontin we determined the influence of gender, age and former asbestos exposure on blood concentrations, assessed the changes over time and investigated characteristics of marker concentrations in prediagnosis samples of patients with mal...

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Bibliographic Details
Published in:Occupational and environmental medicine (London, England) England), 2011-09, Vol.68 (Suppl 1), p.A71-A71
Main Authors: Felten, Michael, Khatab, Khaled, Knoll, Lars, Schettgen, Thomas, Müller-Berndorff, Hendrik, Kraus, Thomas
Format: Article
Language:English
Subjects:
Asbestos
Blood
Lung cancer
Mesothelioma
Occupational exposure
Respiratory diseases
Statistical analysis
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Summary:Objectives For the proposed tumour markers mesothelin and osteopontin we determined the influence of gender, age and former asbestos exposure on blood concentrations, assessed the changes over time and investigated characteristics of marker concentrations in prediagnosis samples of patients with malignant pleural mesothelioma (MPM) and lung cancer (LC). Methods We analysed multiple blood samples of 2262 volunteers of three groups: 1894 formerly asbestos exposed power industry workers, 266 mostly asbestos exposed patients suffering from chronic respiratory diseases and 102 not occupationally exposed controls. Marker concentrations were determined using commercial ELISA kits. For statistical analysis we used the t-test and multiple regression models. Results We measured 3273 and 3218 concentrations of mesothelin and osteopontin respectively. Second, third and fourth samples were obtained in 691, 304 and 72 participants. 16 patients suffering from newly developed MPM or LC could be identified, seven of them had multiple prediagnosis samples. While marker concentrations were associated with age (mesothelin p=0.006, osteopontin p
ISSN:1351-0711
1470-7926
DOI:10.1136/oemed-2011-100382.230