Novel VIM Metallo-{beta}-Lactamase Variant, VIM-24, from a Klebsiella pneumoniae Isolate from Colombia

We report the emergence of a novel VIM variant (VIM-24) in a Klebsiella pneumoniae isolate in Colombia. The isolate displays MICs for carbapenems below the resistance breakpoints, posing a real challenge for its detection. The blaVIM-24 gene was located within a class 1 integron carried on a large p...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2011-05, Vol.55 (5), p.2428-2428
Main Authors: Montealegre, Maria Camila, Correa, Adriana, Briceno, David F, Rosas, Natalia C, De La Cadena, Elsa, Ruiz, Sory J, Mojica, Maria F, Dario Camargo, Ruben, Zuluaga, Ivan, Marin, Adriana
Format: Article
Language:English
Subjects:
Breakpoints
Carbapenems
Klebsiella pneumoniae
Minimum inhibitory concentration
Plasmids
Online Access:Get full text
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Summary:We report the emergence of a novel VIM variant (VIM-24) in a Klebsiella pneumoniae isolate in Colombia. The isolate displays MICs for carbapenems below the resistance breakpoints, posing a real challenge for its detection. The blaVIM-24 gene was located within a class 1 integron carried on a large plasmid. Further studies are needed to clarify its epidemiological and clinical impact.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.01208-10