Electroacupuncture attenuates mechanical and warm allodynia through suppression of spinal glial activation in a rat model of neuropathic pain

Highlights ► Repeated EA showed cumulative analgesic effects on mechanical and warm allodynia. ► Repeated EA suppressed glial activation, MMP-9, MMP-2 and proinflammatory cytokines. ► Repeated EA stimulation might be useful in treating chronic pain clinically.

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Bibliographic Details
Published in:Brain research bulletin 2011-11, Vol.86 (5), p.403-411
Main Authors: Gim, Gyeong-Taek, Lee, Ji-hye, Park, Eunkuk, Sung, Yun-Hee, Kim, Chang-Ju, Hwang, Wei-wan, Chu, Jong-Phil, Min, Byung-Il
Format: Article
Language:English
Subjects:
Animals
Disease Models, Animal
Electroacupuncture
Electroacupuncture - methods
Glial activation
Humans
Hyperalgesia - therapy
Immunoglobulin G - blood
Interleukin-1beta - metabolism
Interleukin-6 - metabolism
Male
Matrix metalloproteinase
Matrix Metalloproteinase 2 - metabolism
Matrix Metalloproteinase 9 - metabolism
Neuralgia - physiopathology
Neuralgia - therapy
Neuroglia - metabolism
Neurology
Neuropathic pain
Pain Measurement
Physical Stimulation - methods
Proinflammatory cytokine
Random Allocation
Rats
Rats, Sprague-Dawley
Spinal Cord - cytology
Temperature
Tumor Necrosis Factor-alpha - metabolism
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Description
Summary:Highlights ► Repeated EA showed cumulative analgesic effects on mechanical and warm allodynia. ► Repeated EA suppressed glial activation, MMP-9, MMP-2 and proinflammatory cytokines. ► Repeated EA stimulation might be useful in treating chronic pain clinically.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2011.09.010