Contribution of N-Glucuronidation to Efavirenz Elimination In Vivo in the Basal and Rifampin-Induced Metabolism of Efavirenz

• Published in: Antimicrobial Agents and Chemotherapy 2011-04, Vol.55 (4), p.1504-1509
• Main Authors: CHO, Doo-Yeoun, OGBURN, Evan T, JONES, David, DESTA, Zeruesenay
• Format: Article
• Language: English
• Subjects: Abundance; Adult; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral Agents; Benzoxazines; Benzoxazines - metabolism; Benzoxazines - pharmacokinetics; Biological and medical sciences; Chromatography, Liquid; Cross-Over Studies; Double-Blind Method; Efavirenz; Female; Glucuronidase - metabolism; Glucuronides; Glucuronides - metabolism; Humans; Hydrolysis; Male; Mass spectroscopy; Medical sciences; Metabolism; Pharmacokinetics; Pharmacology. Drug treatments; Rifampin; Rifampin - pharmacology; Statistical analysis; Tandem Mass Spectrometry; Urine; Young Adult
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.00883-10

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