NK-cells have an impaired response to acute exercise and a lower expression of the inhibitory receptors KLRG1 and CD158a in humans with latent cytomegalovirus infection

Highlight ► Latent CMV infection alters NK-cell inhibitory receptor expression and blunts the exercise-induced mobilization of NK-cells into the blood.

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2012-01, Vol.26 (1), p.177-186
Main Authors: Bigley, Austin B, Lowder, Thomas W, Spielmann, Guillaume, Rector, Jerrald L, Pircher, Hanspeter, Woods, Jeffrey A, Simpson, Richard J
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Anaerobic Threshold - physiology
Antibodies, Monoclonal - immunology
Bicycling - physiology
CD57
CD57 Antigens - biosynthesis
CD57 Antigens - genetics
CD8-Positive T-Lymphocytes - metabolism
Cytomegalovirus
Cytomegalovirus Infections - metabolism
Epstein-Barr virus
Epstein-Barr Virus Infections - metabolism
Exercise - physiology
Exercise immunology
Flow Cytometry
Humans
Immunosenescence
Killer Cells, Natural - metabolism
Killer Cells, Natural - physiology
Lectins, C-Type - biosynthesis
Lectins, C-Type - genetics
Lymphocyte Count
Male
Membrane Proteins - metabolism
Phenotype
Psychiatry
Receptors, KIR2DL1 - biosynthesis
Receptors, KIR2DL1 - genetics
Seropositivity
T-Lymphocytes - physiology
Trans-Activators - biosynthesis
Trans-Activators - genetics
Young Adult
γδ T-cells
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Description
Summary:Highlight ► Latent CMV infection alters NK-cell inhibitory receptor expression and blunts the exercise-induced mobilization of NK-cells into the blood.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2011.09.004