Carnosic acid attenuates renal injury in an experimental model of rat cisplatin-induced nephrotoxicity

• Published in: Food and chemical toxicology 2011-12, Vol.49 (12), p.3090-3097
• Main Authors: Sahu, Bidya Dhar, Rentam, Kiran Kumar Reddy, Putcha, Uday Kumar, Kuncha, Madhusudana, Vegi, Ganga Modi Naidu, Sistla, Ramakrishna
• Format: Article
• Language: English
• Subjects: acid treatment; Acute Kidney Injury - chemically induced; Acute Kidney Injury - pathology; adverse effects; animal models; Animals; Antineoplastic Agents - adverse effects; antioxidants; Antioxidants - pharmacology; Apoptosis; Apoptosis - drug effects; Biological and medical sciences; blood serum; Blood Urea Nitrogen; Carnosic acid; Caspase 3 - genetics; Caspase 3 - metabolism; caspase-3; catalase; Catalase - metabolism; Cisplatin; Cisplatin - adverse effects; creatinine; Creatinine - blood; Disease Models, Animal; Diterpenes, Abietane - pharmacology; Dose-Response Relationship, Drug; Female; Free radicals; glutathione; Glutathione - metabolism; glutathione peroxidase; Glutathione Peroxidase - metabolism; Glutathione Reductase - metabolism; glutathione transferase; Glutathione Transferase - metabolism; glutathione-disulfide reductase; Kidney - cytology; Kidney - drug effects; Kidney - pathology; kidney cells; kidneys; lipid peroxidation; Lipid Peroxidation - drug effects; malondialdehyde; Malondialdehyde - metabolism; Medical sciences; Nephrotoxicity; nitrites; oxidative stress; Oxidative Stress - drug effects; pathogenesis; Plant Extracts - pharmacology; protective effect; Rats; Rats, Wistar; reactive oxygen species; Reactive Oxygen Species - metabolism; superoxide dismutase; Superoxide Dismutase - metabolism; Toxicology; urea nitrogen
• ISSN: 0278-6915; 1873-6351
• DOI: 10.1016/j.fct.2011.08.018

► Nephrotoxicity is the dose limiting side effects of cisplatin, an anticancer agent. ► Carnosic acid significantly attenuated the renal injury, oxidative stress and apoptosis associated with cisplatin therapy. ► Both biochemical and histopathology data correlate the renoprotective effect of carnosic acid. ► Carnosic acid may find role in reducing the complications of renal dysfunction with cisplatin in cancer chemotherapy. Nephrotoxicity is one of the serious dose limiting side effects of cisplatin when used in the treatment of various malignant conditions. Accumulating evidence suggests that oxidative stress caused by free radicals and apoptosis of renal cells contributes to the pathogenesis of cisplatin-induced nephrotoxicity. Present study was aimed to explore the effect of carnosic acid, a potent antioxidant, against cisplatin induced oxidative stress and nephrotoxicity in rats. A single dose of cisplatin (7.5mg/kg) caused marked renal damage, characterized by a significant (P