Comparative Evaluation of Trace Metals in the Blood of Hepatitis C Patients and Healthy Donors

• Published in: Biological trace element research 2011-11, Vol.143 (2), p.751-763
• Main Authors: Saghir, Mehwish, Shaheen, Nazia, Shah, Munir H
• Format: Article
• Language: English
• Subjects: Adult; atomic absorption spectrometry; Atomic absorption spectrophotometry; Biochemistry; Biomedical and Life Sciences; Biotechnology; Blood; Blood & organ donations; Cadmium; Cadmium - blood; calcium; Calcium - blood; Chromium; cobalt; Comparative studies; Copper; Copper - blood; Digestion; gender; Hepatitis; Hepatitis C; Hepatitis C - blood; Humans; iron; Iron - blood; Lead; Lead - blood; Life Sciences; liver; Liver diseases; magnesium; Magnesium - blood; Manganese; Manganese - blood; Metal concentrations; Metals; Middle Aged; Nutrition; Oncology; Patients; Potassium - blood; sodium; Sodium - blood; Spectral analysis; Spectrophotometry; Spectrophotometry, Atomic; statistical analysis; Statistical methods; Statistics; Trace elements; Trace Elements - blood; Trace metals; Zinc; Zinc - blood
• ISSN: 0163-4984; 1559-0720
• DOI: 10.1007/s12011-010-8930-8

Hepatitis C is one of the common types of chronic liver disease, and its plausible association with trace metal imbalance has been investigated in the present study. The blood samples of hepatitis C patients and healthy donors were analysed for trace metals (Ca, Cd, Co, Cr, Cu, Fe, K, Li, Mg, Mn, Na, Pb, and Zn) by flame atomic absorption spectrophotometry after wet acid digestion. In the blood of the hepatitis patients, mean concentrations of essential metals, Na, K, Fe, Ca, Mg, and Zn, were 918.7, 361.0, 102.5, 20.00, 24.66, and 9.429 ppm, respectively, while the mean metal levels in the blood of healthy donors were 1509, 406.8, 232.5, 28.35, 24.59, and 8.799 ppm, respectively. On the average, Cr was significantly higher, while Na, Fe, Ca, Cu, Mn, Pb, and Cd were comparatively lower in the blood of the patients. The correlation study manifested significantly divergent mutual relationships of trace metals in the blood of the patients and healthy donors. Multivariate statistical methods revealed considerably diverse distribution of trace metals in the two groups. Dissimilarity in the trace metal distribution was also noted with the gender and residential location of the donors in both groups.