Effects of Serum from Pregnant Versus Nonpregnant Women on Natural Killer Cell Activity

PROBLEM: To test the effect of serum obtained from in vitro fertilization‐embryo transfer (IVF‐ET) patients on the healthy volunteers natural killer (NK) cell activity. METHOD OF STUDY: Retrospective non‐randomized clinical study. Suppressive effect on NK cell activity was measured with serum obtain...

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Bibliographic Details
Published in:American journal of reproductive immunology (1989) 1997-05, Vol.37 (5), p.365-367
Main Authors: Fujino, Yuji, Nakamura, Yoshihiro, Ueda, Kayoko, Ozaki, Kouji, Ito, Fumitoshi, Sun, Ting-Ting, Umesaki, Naohiko, Ogita, Sachio
Format: Article
Language:English
Subjects:
In vitro fertilization and embryo transfer
Natural killer cells
NK cell
Pregnancy
serum effect
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Summary:PROBLEM: To test the effect of serum obtained from in vitro fertilization‐embryo transfer (IVF‐ET) patients on the healthy volunteers natural killer (NK) cell activity. METHOD OF STUDY: Retrospective non‐randomized clinical study. Suppressive effect on NK cell activity was measured with serum obtained from 25 pregnant and 24 non‐pregnant women during IVF‐ET procedure. RESULTS: Suppressive serum effect of volunteers' NK cell activity was significantly higher in pregnant than in non‐pregnant women (P < 0.01). CONCLUSIONS: The suppressive activity of serum from pregnant women on NK cell suppression activity was useful in predicting the establishment of a successful pregnancy.
ISSN:1046-7408
1600-0897
DOI:10.1111/j.1600-0897.1997.tb00245.x