Eosinophils regulate dendritic cells and Th2 pulmonary immune responses following allergen provocation

Reports have recently suggested that eosinophils have the potential to modulate allergen-dependent pulmonary immune responses. The studies presented expand these reports demonstrating in the mouse that eosinophils are required for the allergen-dependent Th2 pulmonary immune responses mediated by den...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of immunology (1950) 2011-12, Vol.187 (11), p.6059-6068
Main Authors: Jacobsen, Elizabeth A, Zellner, Katie R, Colbert, Dana, Lee, Nancy A, Lee, James J
Format: Article
Language:English
Subjects:
Adoptive Transfer
Allergens - immunology
Animals
Asthma - immunology
Cell Separation
Chemotaxis, Leukocyte - immunology
Dendritic Cells - immunology
Eosinophils - immunology
Flow Cytometry
Hypersensitivity - immunology
Immunity, Mucosal - immunology
Lung - immunology
Lymphocyte Activation - immunology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Ovalbumin - immunology
Th2 Cells - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Reports have recently suggested that eosinophils have the potential to modulate allergen-dependent pulmonary immune responses. The studies presented expand these reports demonstrating in the mouse that eosinophils are required for the allergen-dependent Th2 pulmonary immune responses mediated by dendritic cells (DCs) and T lymphocytes. Specifically, the recruitment of peripheral eosinophils to the pulmonary lymphatic compartment(s) was required for the accumulation of myeloid DCs in draining lymph nodes and, in turn, Ag-specific T effector cell production. These effects on DCs and Ag-specific T cells did not require MHC class II expression on eosinophils, suggesting that these granulocytes have an accessory role as opposed to direct T cell stimulation. The data also showed that eosinophils uniquely suppress the DC-mediated production of Th17 and, to smaller degree, Th1 responses. The cumulative effect of these eosinophil-dependent immune mechanisms is to promote the Th2 polarization characteristic of the pulmonary microenvironment after allergen challenge.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.1102299