MeCP2 controls the expression of RASAL1 in the hepatic fibrosis in rats

Highlights ► MeCP2 is induced in liver wound healing and fibrosis. ► Epigenetic controls of RASAL1 provide bases for perpetuating fibroblast activation. ► MeCP2 modifications RASAL1 expression.

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Bibliographic Details
Published in:Toxicology (Amsterdam) 2011-12, Vol.290 (2), p.327-333
Main Authors: Tao, Hui, Huang, Cheng, Yang, Jing-Jing, Ma, Tao-Tao, Bian, Er-Bao, Zhang, Lei, Lv, Xiong-Wen, Jin, Yong, Li, Jun
Format: Article
Language:English
Subjects:
Animals
Azacitidine - analogs & derivatives
Azacitidine - pharmacology
Biological and medical sciences
cell proliferation
Cell Proliferation - drug effects
chromatin
DNA Methylation
Emergency
Extracellular signal-regulated kinase signaling
fibroblasts
fibrosis
Gastroenterology. Liver. Pancreas. Abdomen
Gene Knockdown Techniques
guanosinetriphosphatase
Hepatic stellate cells
Hepatic Stellate Cells - metabolism
liver
Liver Cirrhosis - pathology
Liver fibrosis
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
messenger RNA
Methyl-CpG-binding protein 2
Methyl-CpG-Binding Protein 2 - genetics
Methyl-CpG-Binding Protein 2 - metabolism
Myofibroblasts - metabolism
Other diseases. Semiology
Ras GTPase activating-like protein 1
ras GTPase-Activating Proteins - genetics
Rats
Rats, Sprague-Dawley
RNA, Messenger - metabolism
RNA, Small Interfering - metabolism
small interfering RNA
Toxicology
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Description
Summary:Highlights ► MeCP2 is induced in liver wound healing and fibrosis. ► Epigenetic controls of RASAL1 provide bases for perpetuating fibroblast activation. ► MeCP2 modifications RASAL1 expression.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2011.10.011