Occupational exposure to organic dust increases lung cancer risk in the general population

Objectives Organic dust is a mixture of particulate matter from microbial, plant or animal origin. Increased lung cancer risks have been reported for occupations with exposure to animal products (eg, butchers), while exposure to microbial components (eg, endotoxin) has been associated with decreased...

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Published in:Occupational and environmental medicine (London, England) England), 2011-09, Vol.68 (Suppl 1), p.A46-A47
Main Authors: Peters, Susan, Kromhout, Hans, Olsson, Ann, Wuchmann, Heinz-Erich, Brüske, Irene, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil, Siemiatycki, Jack, Richiardi, Lorenzo, Mirabelli, Dario, Simonato, Lorenzo, Gustavsson, Per, Plato, Nils, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Boffetta, Paolo, Brennan, Paul, Zaridze, David, Cassidy, Adrian, Lissowska, Jolanta, Szeszenia-Dabrowska, Neonila, Rudnai, Peter, Fabianova, Eleonora, Forastiere, Francesco, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Stücker, Isabelle, Dumitru, Rodica Stanescu, Benhamou, Simone, Bueno-de-Mesquita, Bas, Kendzia, Benjamin, Pesch, Beate, Straif, Kurt, Brüning, Thomas, Vermeulen, Roel
Format: Article
Language:English
Subjects:
Animal products
Cancer
Dust
Endotoxins
Health risks
Lung cancer
Occupational exposure
Particulate matter
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Summary:Objectives Organic dust is a mixture of particulate matter from microbial, plant or animal origin. Increased lung cancer risks have been reported for occupations with exposure to animal products (eg, butchers), while exposure to microbial components (eg, endotoxin) has been associated with decreased lung cancer risks. To date there has not been a comprehensive evaluation of the possible association between organic dust exposure and its specific constituents and lung cancer risk in the general population. Methods The SYNERGY project pooled information on lifetime work histories and smoking from 13 300 lung cancer cases and 16 273 controls from 11 case-control studies conducted in Europe and Canada. A job exposure matrix for exposure to organic dust, endotoxin, and contact with animals or fresh animal products was applied to determine level of exposure. ORs for lung cancer were estimated by logistic regression, adjusted for age, gender, study, cigarette pack-years, time-since-quitting smoking, and ever employment in occupations with established lung cancer risk. Results Organic dust exposure was associated with increased lung cancer risk. The second to the fourth quartile of cumulative exposure showed significant risk estimates ranging from 1.12 to 1.24 in a dose-dependent manner (p-value
ISSN:1351-0711
1470-7926
DOI:10.1136/oemed-2011-100382.151