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A Novel Monoclonal Antibody against Human CD80 and its Immune Protection in a Mouse Lupus-like Disease
Blockade of the interactions between CD28/CTLA-4 and their ligands, CD80 (B7, B7.1)/CD86 (B70, B7.2), is an attractive means to induce antigen-specific peripheral tolerance in autoimmune disease and organ transplantation. In this study, we generated and characterized a monoclonal antibody (Clone 4E5...
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| Published in: | International journal of immunopathology and pharmacology 2011-07, Vol.24 (3), p.583-593 |
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| Main Authors: | , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c418t-d48d1bf4f12413727cd04339ac43d68db20be4fe72bb9e288472d98bad2820df3 |
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| cites | cdi_FETCH-LOGICAL-c418t-d48d1bf4f12413727cd04339ac43d68db20be4fe72bb9e288472d98bad2820df3 |
| container_end_page | 593 |
| container_issue | 3 |
| container_start_page | 583 |
| container_title | International journal of immunopathology and pharmacology |
| container_volume | 24 |
| creator | Shi, Q. Gao, Z.Y. Xie, F. Wang, L.F. Gu, Y.P. Yang, T.J. Huang, L. Qian, Q.H. Qiu, Y.H. |
| description | Blockade of the interactions between CD28/CTLA-4 and their ligands, CD80 (B7, B7.1)/CD86 (B70, B7.2), is an attractive means to induce antigen-specific peripheral tolerance in autoimmune disease and organ transplantation. In this study, we generated and characterized a monoclonal antibody (Clone 4E5) against human CD80. 4E5 could recognize both human and mouse CD80 and suppress mixed lymphocyte reaction in vitro. To investigate their potency for clinical use, we further administrated 4E5 to a mouse lupus-like disease model (C57BL/J6) induced by Pristane. 4E5 could inhibit the immune response and attenuate the severity of lupus-like disease. The data showed 4E5 function and suggested that blockade of CD80/CD28 co-stimulatory signal pathway with 4E5 is a promising strategy to decelerate the progression of lupus-like disease and other autoimmune diseases. |
| doi_str_mv | 10.1177/039463201102400304 |
| format | article |
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The data showed 4E5 function and suggested that blockade of CD80/CD28 co-stimulatory signal pathway with 4E5 is a promising strategy to decelerate the progression of lupus-like disease and other autoimmune diseases.</description><identifier>ISSN: 0394-6320</identifier><identifier>EISSN: 2058-7384</identifier><identifier>DOI: 10.1177/039463201102400304</identifier><identifier>PMID: 21978690</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Antibodies, Antinuclear - pharmacology ; Antibodies, Monoclonal - chemistry ; Antibodies, Monoclonal - pharmacology ; Antibodies, Monoclonal - therapeutic use ; Antigens, CD - biosynthesis ; Antigens, CD - genetics ; B7-1 Antigen - immunology ; CD28 Antigens - drug effects ; CD28 Antigens - physiology ; Cell Line ; Cell Proliferation - drug effects ; Disease Models, Animal ; Flow Cytometry ; Fluorescent Antibody Technique ; Humans ; Immunosuppressive Agents ; Kidney - immunology ; Lupus Erythematosus, Systemic - chemically induced ; Lupus Erythematosus, Systemic - drug therapy ; Lupus Nephritis - chemically induced ; Lupus Nephritis - pathology ; Lymphocyte Culture Test, Mixed ; Mice ; Mice, Inbred C57BL ; Signal Transduction - drug effects ; Spleen - cytology ; Spleen - drug effects ; T-Lymphocytes - drug effects ; Terpenes</subject><ispartof>International journal of immunopathology and pharmacology, 2011-07, Vol.24 (3), p.583-593</ispartof><rights>2011 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-d48d1bf4f12413727cd04339ac43d68db20be4fe72bb9e288472d98bad2820df3</citedby><cites>FETCH-LOGICAL-c418t-d48d1bf4f12413727cd04339ac43d68db20be4fe72bb9e288472d98bad2820df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/039463201102400304$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/039463201102400304$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21966,27853,27924,27925,44945,45333</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/039463201102400304?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21978690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shi, Q.</creatorcontrib><creatorcontrib>Gao, Z.Y.</creatorcontrib><creatorcontrib>Xie, F.</creatorcontrib><creatorcontrib>Wang, L.F.</creatorcontrib><creatorcontrib>Gu, Y.P.</creatorcontrib><creatorcontrib>Yang, T.J.</creatorcontrib><creatorcontrib>Huang, L.</creatorcontrib><creatorcontrib>Qian, Q.H.</creatorcontrib><creatorcontrib>Qiu, Y.H.</creatorcontrib><title>A Novel Monoclonal Antibody against Human CD80 and its Immune Protection in a Mouse Lupus-like Disease</title><title>International journal of immunopathology and pharmacology</title><addtitle>Int J Immunopathol Pharmacol</addtitle><description>Blockade of the interactions between CD28/CTLA-4 and their ligands, CD80 (B7, B7.1)/CD86 (B70, B7.2), is an attractive means to induce antigen-specific peripheral tolerance in autoimmune disease and organ transplantation. 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Gao, Z.Y. ; Xie, F. ; Wang, L.F. ; Gu, Y.P. ; Yang, T.J. ; Huang, L. ; Qian, Q.H. ; Qiu, Y.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-d48d1bf4f12413727cd04339ac43d68db20be4fe72bb9e288472d98bad2820df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Antibodies, Antinuclear - pharmacology</topic><topic>Antibodies, Monoclonal - chemistry</topic><topic>Antibodies, Monoclonal - pharmacology</topic><topic>Antibodies, Monoclonal - therapeutic use</topic><topic>Antigens, CD - biosynthesis</topic><topic>Antigens, CD - genetics</topic><topic>B7-1 Antigen - immunology</topic><topic>CD28 Antigens - drug effects</topic><topic>CD28 Antigens - physiology</topic><topic>Cell Line</topic><topic>Cell Proliferation - drug effects</topic><topic>Disease Models, Animal</topic><topic>Flow Cytometry</topic><topic>Fluorescent Antibody Technique</topic><topic>Humans</topic><topic>Immunosuppressive Agents</topic><topic>Kidney - immunology</topic><topic>Lupus Erythematosus, Systemic - chemically induced</topic><topic>Lupus Erythematosus, Systemic - drug therapy</topic><topic>Lupus Nephritis - chemically induced</topic><topic>Lupus Nephritis - pathology</topic><topic>Lymphocyte Culture Test, Mixed</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Signal Transduction - drug effects</topic><topic>Spleen - cytology</topic><topic>Spleen - drug effects</topic><topic>T-Lymphocytes - drug effects</topic><topic>Terpenes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shi, Q.</creatorcontrib><creatorcontrib>Gao, Z.Y.</creatorcontrib><creatorcontrib>Xie, F.</creatorcontrib><creatorcontrib>Wang, L.F.</creatorcontrib><creatorcontrib>Gu, Y.P.</creatorcontrib><creatorcontrib>Yang, T.J.</creatorcontrib><creatorcontrib>Huang, L.</creatorcontrib><creatorcontrib>Qian, Q.H.</creatorcontrib><creatorcontrib>Qiu, Y.H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>International journal of immunopathology and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Shi, Q.</au><au>Gao, Z.Y.</au><au>Xie, F.</au><au>Wang, L.F.</au><au>Gu, Y.P.</au><au>Yang, T.J.</au><au>Huang, L.</au><au>Qian, Q.H.</au><au>Qiu, Y.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Novel Monoclonal Antibody against Human CD80 and its Immune Protection in a Mouse Lupus-like Disease</atitle><jtitle>International journal of immunopathology and pharmacology</jtitle><addtitle>Int J Immunopathol Pharmacol</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>24</volume><issue>3</issue><spage>583</spage><epage>593</epage><pages>583-593</pages><issn>0394-6320</issn><eissn>2058-7384</eissn><abstract>Blockade of the interactions between CD28/CTLA-4 and their ligands, CD80 (B7, B7.1)/CD86 (B70, B7.2), is an attractive means to induce antigen-specific peripheral tolerance in autoimmune disease and organ transplantation. 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| identifier | ISSN: 0394-6320 |
| ispartof | International journal of immunopathology and pharmacology, 2011-07, Vol.24 (3), p.583-593 |
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| language | eng |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Animals Antibodies, Antinuclear - pharmacology Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Antigens, CD - biosynthesis Antigens, CD - genetics B7-1 Antigen - immunology CD28 Antigens - drug effects CD28 Antigens - physiology Cell Line Cell Proliferation - drug effects Disease Models, Animal Flow Cytometry Fluorescent Antibody Technique Humans Immunosuppressive Agents Kidney - immunology Lupus Erythematosus, Systemic - chemically induced Lupus Erythematosus, Systemic - drug therapy Lupus Nephritis - chemically induced Lupus Nephritis - pathology Lymphocyte Culture Test, Mixed Mice Mice, Inbred C57BL Signal Transduction - drug effects Spleen - cytology Spleen - drug effects T-Lymphocytes - drug effects Terpenes |
| title | A Novel Monoclonal Antibody against Human CD80 and its Immune Protection in a Mouse Lupus-like Disease |
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