Antigenic mimicry-mediated anti-prion effects induced by bacterial enzyme succinylarginine dihydrolase in mice

Highlights ► In this study, we immunized mice with the bacterial molecules SADH( E ) and SADH( S ). ► These molecules carry a sequence similar to the 6H4 anti-prion epitope. ► The immunization elicited anti-prion Abs and attenuated prion disease in mice. ► Antigenic mimicry-based prion vaccines migh...

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Bibliographic Details
Published in:Vaccine 2011-11, Vol.29 (50), p.9321-9328
Main Authors: Ishibashi, Daisuke, Yamanaka, Hitoki, Mori, Tsuyoshi, Yamaguchi, Naohiro, Yamaguchi, Yoshitaka, Nishida, Noriyuki, Sakaguchi, Suehiro
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antibody Formation
Antigenic mimicry
Applied microbiology
Autoantibodies
Autoantibodies - immunology
Bacteria
Bacterial Proteins - administration & dosage
Bacterial Proteins - immunology
Biological and medical sciences
cattle
Creutzfeldt-Jakob disease
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Deoxyribonucleic acid
DNA
E coli
Enzymes
Epitopes
Epitopes - immunology
Female
Fundamental and applied biological sciences. Psychology
Humoral immunity
Hydrolases - administration & dosage
Hydrolases - immunology
Immunization
Immunological tolerance
Infections
Mammals
Medical sciences
Mice
Mice, Inbred BALB C
Microbiology
Mimicry
Molecular Mimicry
Neurology
Non conventional transmissible agents
Prion
prion diseases
Prion Diseases - immunology
Prion Diseases - prevention & control
Prion protein
Prions
Prions - administration & dosage
Prions - immunology
Proteins
Recombinant Proteins - administration & dosage
Recombinant Proteins - immunology
sheep
Studies
Survival
Vaccine
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Summary:Highlights ► In this study, we immunized mice with the bacterial molecules SADH( E ) and SADH( S ). ► These molecules carry a sequence similar to the 6H4 anti-prion epitope. ► The immunization elicited anti-prion Abs and attenuated prion disease in mice. ► Antigenic mimicry-based prion vaccines might be a new type of prion vaccine.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2011.10.017