Active immunization against IL-23p19 improves experimental arthritis

Highlights ► Murine IL-23p19 subunit has been modeled in silico. ► Peptides from IL-23p19 were coupled to KLH and used as vaccine for CIA. ► Mice vaccinated against IL-23p19 peptide developed less arthritis than controls. ► Targeting IL-23p19 might constitute a promising therapeutic approach in arth...

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Bibliographic Details
Published in:Vaccine 2011-11, Vol.29 (50), p.9329-9336
Main Authors: Ratsimandresy, Rojo Anthony, Duvallet, Emilie, Assier, Eric, Semerano, Luca, Delavallée, Laure, Bessis, Natacha, Zagury, Jean-François, Boissier, Marie-Christophe
Format: Article
Language:English
Subjects:
Acquisitions & mergers
Allergy and Immunology
animal models
Animals
antibodies
Antibodies, Neutralizing - immunology
Antibody Formation
Applied microbiology
Arthritis
Arthritis, Experimental - chemically induced
Arthritis, Experimental - immunology
Arthritis, Experimental - therapy
Autoimmune diseases
Binding Sites
bioinformatics
Biological and medical sciences
cattle
collagen
Colleges & universities
Cytokines
Cytokines - immunology
Disease
enzyme-linked immunosorbent assay
Female
Freund's Adjuvant - pharmacology
Fundamental and applied biological sciences. Psychology
Hemocyanins - pharmacology
IL-23p19
Immunization
inflammation
interleukin-10
interleukin-12
interleukin-17
interleukin-1beta
interleukin-23
Interleukin-23 Subunit p19 - immunology
Lipids - pharmacology
Lymphocytes
Male
messenger RNA
Mice
Mice, Inbred DBA
Microbiology
Neutralization Tests
Peptides
Protein Structure, Tertiary
Rabbits
reverse transcriptase polymerase chain reaction
Rheumatoid arthritis
Spleen
Spleen - cytology
Spleen - immunology
T-lymphocytes
T-Lymphocytes - immunology
tumor necrosis factor-alpha
Vaccination
vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Subunit - immunology
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Summary:Highlights ► Murine IL-23p19 subunit has been modeled in silico. ► Peptides from IL-23p19 were coupled to KLH and used as vaccine for CIA. ► Mice vaccinated against IL-23p19 peptide developed less arthritis than controls. ► Targeting IL-23p19 might constitute a promising therapeutic approach in arthritis.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2011.09.134