The functional polymorphisms -429T>C and -374T>A of the RAGE gene promoter are not associated with gestational diabetes in Euro-Brazilians

The receptor for advanced glycation end products (RAGE or AGER) is a multiligand member of the immunoglobulin superfamily. RAGE is expressed in several tissues, including human myometrium, chorionic villi and placenta. Advanced glycation end products are the best studied ligands of RAGE; they have p...

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Bibliographic Details
Published in:Genetics and molecular research 2010, Vol.9 (2), p.1130-1135
Main Authors: Santos, I C R, Daga, D R, Frigeri, H R, Réa, R R, Almeida, A C R, Souza, E M, Pedrosa, F O, Fadel-Picheth, C M T, Picheth, G
Format: Article
Language:English
Subjects:
Adult
Brazil
Diabetes, Gestational - ethnology
Diabetes, Gestational - genetics
Europe
Female
Glycated Hemoglobin A - genetics
Humans
Immunoglobulins - metabolism
Insulin - metabolism
Ligands
Polymerase Chain Reaction - methods
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Pregnancy
Promoter Regions, Genetic
Receptor for Advanced Glycation End Products - genetics
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Summary:The receptor for advanced glycation end products (RAGE or AGER) is a multiligand member of the immunoglobulin superfamily. RAGE is expressed in several tissues, including human myometrium, chorionic villi and placenta. Advanced glycation end products are the best studied ligands of RAGE; they have pro-inflammatory actions in human gestational tissues, increasing oxidative stress and the release of cytokines and prostaglandins. We investigated the association of RAGE gene promoter polymorphisms -429T>C (rs1800625) and -374T>A (rs1800624) with gestational diabetes. A sample of 750 unrelated European origin pregnant Brazilian women were classified as nondiabetic (control group, N = 600) or having gestational diabetes (N = 150) according to American Diabetes Association 2009 criteria. Genotyping was performed by PCR-RFLP. The frequencies of the rare alleles -429C (6.3 versus 9.1%) and -374A (26 versus 30%) were not significantly different between the gestational diabetes patients and healthy pregnant women. Also, the -429T>C and -374T>A polymorphisms were not associated with body mass index, lipid profile, fasting glycemia, HbA1C, or insulin requirement. We found that functional promoter polymorphisms of the RAGE gene were not associated with gestational diabetes or its complications in these Euro-Brazilian patients.
ISSN:1676-5680
1676-5680
DOI:10.4238/vol9-2gmr817