In vitro assessment of the antiviral potential of trans-cinnamic acid, quercetin and morin against equid herpesvirus 1

The antiviral activity of quercetin, morin and trans-cinnamic acid was evaluated in vitro against equid herpesvirus 1 (EHV-1) by determining the virucidal activity and using the time of addition assay to test inhibition of the viral replication cycle. The cytotoxicity of each substance was assessed...

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Bibliographic Details
Published in:Research in veterinary science 2011-12, Vol.91 (3), p.e158-e162
Main Authors: Gravina, H.D., Tafuri, N.F., Silva Júnior, A., Fietto, J.L.R., Oliveira, T.T., Diaz, M.A.N., Almeida, M.R.
Format: Article
Language:English
Subjects:
Acids
Animals
Antiviral activity
Antiviral Agents - pharmacology
Berries
Chlorocebus aethiops
Cinnamates - pharmacology
EHV-1
Flavonoids
Flavonoids - pharmacology
Food science
Herpesvirus
Herpesvirus 1, Equid - drug effects
Proteins
Quercetin - pharmacology
Vero Cells
Veterinary medicine
Viruses
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Summary:The antiviral activity of quercetin, morin and trans-cinnamic acid was evaluated in vitro against equid herpesvirus 1 (EHV-1) by determining the virucidal activity and using the time of addition assay to test inhibition of the viral replication cycle. The cytotoxicity of each substance was assessed using MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide]. Quercetin showed virucidal action and inhibition of the viral replication cycle at 0 and 1 h. Morin showed potential virucidal and viral replication cycle inhibition at 0 h. Trans-cinnamic acid did not show virucidal activity but inhibited the viral replication cycle at −1 and 0 h. This study demonstrates the potential of these compounds as future antiviral candidates in relation to viruses of importance in veterinary medicine.
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2010.11.010