Efficacy of vitamins supplementation to therapy on Helicobacter pylori eradication in patients with low antioxidant capacity

• Published in: Clinics and research in hepatology and gastroenterology 2011-11, Vol.35 (11), p.745-749
• Main Authors: Sezikli, Mesut, Çetinkaya, Züleyha Akkan, Güzelbulut, Fatih, Sezikli, Hayrünnisa, Özkara, Selvinaz, Coşgun, Süleyman, Gönen, Can, Övünç, Ayşe Oya Kurdaş
• Format: Article
• Language: English
• Subjects: Adult; Antioxidants - therapeutic use; Ascorbic Acid - therapeutic use; Bacterial diseases; Bacterial diseases of the digestive system and abdomen; Biological and medical sciences; Dietary Supplements; Diseases of the digestive system; Female; Gastroenterology and Hepatology; Gastroenterology. Liver. Pancreas. Abdomen; Helicobacter Infections - drug therapy; Helicobacter Infections - metabolism; Helicobacter pylori; Human bacterial diseases; Humans; Infectious diseases; Internal Medicine; Male; Medical sciences; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Vitamin E - therapeutic use
• ISSN: 2210-7401; 2210-741X
• DOI: 10.1016/j.clinre.2011.07.001

Summary Background and objectives It was shown that supplementation of vitamins C and E to therapy increased Helicobacter pylori eradication rate. In the present study, we aimed to evaluate whether supplementation of antioxidant vitamins to therapy increases H. pylori eradication rates in patients with chronic stress and low antioxidant capacity. Methods This study included 120 patients who presented to gastroenterology outpatient clinic with H. pylori -positive nonulcer dyspepsia and low total antioxidant capacity. Patients in group A ( n = 80) were given lansoprazole (30 mg, BID), amoxicillin (1000 mg, BID), and clarithromycin (500 mg, BID) for 14 days, as well as vitamin C (500 mg, BID) and vitamin E (200 IU, BID) for 30 days. Patients in group B ( n = 40) were given lansoprazole (30 mg, BID), amoxicillin (1000 mg, BID), and clarithromycin (500 mg, BID) for 14 days. Results Total antioxidant capacity were lower than normal levels in all patients. One hundred and fifteen patients (77 in group A, 38 in group B) were analyzed with per protocol analysis. In group A, H. pylori eradication was achieved in 63.8% of the patients included in the intention to treat analysis and in 66.2% of the patients included in the per protocol analysis. In group B, H. pylori eradication was achieved in 42.5% of the patients included in the intention to treat analysis and in 44.7% of the patients included in the per protocol analysis. Eradication rates were significantly higher in group A than in group B ( P < 0.005). Conclusions Supplementation with vitamins C and E increased H. pylori eradication rate of standard triple therapy.