Effect of exercise intensity on albuminuria in adolescents with Type 1 diabetes mellitus

• Published in: Diabetic medicine 2012-01, Vol.29 (1), p.70-73
• Main Authors: Kornhauser, C., Malacara, J.-M., Macías-Cervantes, M.-H., Rivera-Cisneros, A.-E.
• Format: Article
• Language: English
• Subjects: Adolescent; Albuminuria - etiology; Associated diseases and complications; Biological and medical sciences; Biomarkers - blood; Blood Pressure; Body Composition; Child; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - physiopathology; Diabetes. Impaired glucose tolerance; Electrocardiography; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Exercise; Exercise Test; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Glycated Hemoglobin A - metabolism; Humans; Male; Medical sciences; microalbuminuria; Oxygen Consumption; Predictive Value of Tests; Sex Distribution; Time Factors; Type 1 diabetes mellitus; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology
• ISSN: 0742-3071; 1464-5491
• DOI: 10.1111/j.1464-5491.2011.03380.x

Diabet. Med. 29, 70–73 (2012) Aims  Exercise may be useful to detect patients with diabetes prone to develop persistent microalbuminuria. We studied the relationship between exercise intensity, measured as maximal oxygen consumption (VO2 max), and microalbuminuria in patients with Type 1 diabetes mellitus patients. Methods  We studied 10 patients, age range 10–18 years, with Type 1 diabetes who were normotensive and normoalbuminuric, with less than 10 years since diagnosis. Patients had normal renal function, without infections or clinical evidence of complications. Metabolic control was intensively adjusted in all patients. They underwent three consecutive physical exercise tests, reaching 100, 80 and 60% of the maximal cardiac frequency response. Results  Eight patients had adequate to regular metabolic control. All patients had lower than predicted VO2 max values. At 60%, only three patients showed microalbuminuria in excess of 20 μg/min, two of them had inadequate metabolic control. Post‐exercise microalbuminuria exceeded normal values in nine, seven and three patients when submitted to 100, 80 and 60% of exercise intensity, respectively. Conclusions  Microalbuminuria increased with exercise intensity. Sex, body composition and VO2 max were the main factors associated with microalbuminuria. The prognostic significance of albuminuria induced by intense exercise in these subjects with Type 1 diabetes is not yet known.